Chinese Medicine for Treating Chronic Pharyngolaryngitis

Last updated: July 5, 2023
Sponsor: Chinese University of Hong Kong
Overall Status: Active - Recruiting

Phase

2

Condition

Pharyngitis

Treatment

Qingyan Lihou Decoction

Placebo

Clinical Study ID

NCT05665777
CP study
  • Ages > 18
  • All Genders

Study Summary

A randomized, double-blinded, placebo-controlled clinical trial using a Chinese Medicine formula in treating Chronic pharyngolaryngitis. Subjects will be randomized into a treatment group or placebo group for 8 weeks, and then followed by an 8-week post-treatment visit.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 18 years of age or above (Chinese subjects only);
  • Persistent symptoms of pharyngitis (sore throat, globus, dry throat, dry cough, throatirritation) for more than 3 weeks;
  • Determined to be the following Chinese medicine syndromes by Registered ChineseMedicine Practitioners (RCMPs): Wind-heat invading the upper-jiao, or phlegm heat orYin deficiency;
  • Visual analog scale (VAS) score for pain ≥ 50 mm;
  • Numeric rating scale (NRS) ≥ 6; and
  • Be able to give voluntary written informed consent.

Exclusion

Exclusion Criteria:

  • Known severe medical conditions, such as cardiovascular, liver or renal dysfunction,diabetes mellitus, cancers, cerebrovascular diseases, blood system diseases;
  • Concomitant use of steroids, nonsteroidal anti-inflammatory drugs (NSAIDs),anticoagulants, and immunotherapy within the past week;
  • Impaired hematological profile and liver / renal function exceed the upper limit ofthe reference value by 2 times;
  • Known Allergic rhinitis;
  • Known Gastroesophageal Reflux Disease (GERD);
  • Known cancer or suspected cancer of throat/oesophagus;
  • Mechanical obstruction of the throat accountable for the symptoms;
  • Known alcohol and/or drug abuse;
  • Known allergic history to any Chinese herbal medicines; and
  • Subjects who are known pregnant or lactating.

Study Design

Total Participants: 74
Treatment Group(s): 2
Primary Treatment: Qingyan Lihou Decoction
Phase: 2
Study Start date:
March 30, 2023
Estimated Completion Date:
July 31, 2025

Study Description

Chronic pharyngolaryngitis (CP), also known as chronic pharyngitis, is defined as the inflammation of the pharynx, which is at the back of the throat. CP is a common disease characterized by dry throat, sore throat, pharyngeal itching, dry cough, and difficulty in swallowing. In Western medicine, common treatment regimens for CP include lozenges, antibiotics, lasers, and cryotherapy. However, the above treatment modalities may not be effective, and the disease is likely to bounce back repeatedly.

Chinese medicine has been used for the treatment of CP for a long time. Many studies have shown that treatment using Chinese herbal medicine is effective in relieving the symptoms of CP.

This study is to evaluate the efficacy and safety of oral Qingyan Lihou Decoction in relieving the clinical symptoms of patients with CP.

Connect with a study center

  • Hong Kong Institute of Integrative Medicine

    Hong Kong,
    Hong Kong

    Active - Recruiting

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