Improvement of Fertilization Rate and Embryo Quality by Treating Calcium Ionophore in IVF Patients: a Sibling Oocyte Control Study

Last updated: March 18, 2026
Sponsor: Chang Gung Memorial Hospital
Overall Status: Completed

Phase

N/A

Condition

Infertility

In Vitro Fertilization

Treatment

calcium ionophore

Clinical Study ID

NCT05722067
202200969A3
  • Ages 20-50
  • Female

Study Summary

GM508 CultActive is a bicarbonate buffered reagent and ready-to-use designed to investigate oocytes of patients with failed fertilization after previous Intracytoplasmatic Sperm Injection cycles. The investigators hypothesize that GM508 CultActive will improve the fertilization rate and embryo development of such IVF patients (a history of poor fertilization, a history of poor embryo quality, and over 40 years old expected challenging to conceive).

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Low fertilization rate in previous IVF cycle (<30%), or

  • Poor embryo developmental problems in previous IVF cycle, or

  • Diminished ovarian reserve (AMH<1.2 or AFC<5) and/or more than 40 y/o.

Exclusion

Exclusion Criteria:

  • Without or just one oocyte picked up

Study Design

Total Participants: 68
Treatment Group(s): 1
Primary Treatment: calcium ionophore
Phase:
Study Start date:
January 01, 2023
Estimated Completion Date:
June 30, 2025

Connect with a study center

  • Chang Gung Memorial Hospital

    Kaohsiung, 123
    Taiwan

    Site Not Available

  • Chang Gung Memorial Hospital

    Kaohsiung City, 123
    Taiwan

    Site Not Available

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