Induction Lorlatinib in Stage III Non-small Cell Lung Cancer

Inclusion Criteria:

• Age :18 Years to 75 Years;

• ECOG physical score 0-2 points; expected survival time ≥ 1 year;

• Pathologically confirmed diagnosis with Stage III NSCLC which harbored ALK fusiondetected by next generation sequencing (NGS) or immunohistochemistry (IHC) with orwithout FISH. Suspected N2 (station 2/4/7) for stage III disease should be confirmedby either mediastinoscopy or EBUS.

• At least one measurable target lesion according to the RECIST 1.1 standard;

• The main organ function meets the following criteria: 1) blood routine: absolutevalue of neutrophils ≥ 1.5 × 109 / L, platelets ≥ 75 × 109 / L, hemoglobin ≥ 80 g /L; 2) blood biochemistry: total bilirubin ≤ 1.5 times the upper limit of normalvalue, aspartate aminotransferase and alanine aminotransferase ≤ 2.5 times the upperlimit of normal value (if liver metastasis, ≤ upper limit of normal value 5 times),serum creatinine ≤ 1.5 times the upper limit of normal;

• Subjects voluntarily joined the study and signed informed consent, with goodcompliance to follow-up.

Exclusion Criteria:

• Stage I, stage II and metastatic stage IV NSCLC;

• Histologically confirmed small cell lung cancer (including lung cancer mixed withsmall cell lung cancer and non-small cell lung cancer);

• Patients who have previously used any other anti-tumor drugs or receivedsurgery/radiotherapy;

• Patients with any underlying disease that investigators consider it may affectpatient's prognosis including sever cardiovascular, pulmonary disease or seriousinfections.

• Clinically obvious gastrointestinal abnormalities, which may affect the intake,transport or absorption of drugs (such as inability to swallow, chronic diarrhea,intestinal obstruction, etc.), or patients with total gastrectomy;

• Pregnant or lactating women; those who have fertility are unwilling or unable totake effective contraceptive measures;

• Patients with low compliance or willingness to take the drugs and surveillance.