Effect of Diosmin and Hesperidin in Treatment of Patients With Rheumatoid Arthritis

Last updated: April 24, 2025
Sponsor: Alexandria University
Overall Status: Active - Recruiting

Phase

3

Condition

Dermatomyositis (Connective Tissue Disease)

Arthritis And Arthritic Pain

Rheumatoid Arthritis

Treatment

Diosmin and Hesperidin Combination

Clinical Study ID

NCT05756179
0201734
  • Ages 19-65
  • All Genders

Study Summary

Evaluating the effect of the flavonoids combination (diosmin and hesperidin) as adjuvant therapy on patients with rheumatoid arthritis

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patients with mild to moderate disease activity.

  • Patient age must be more than 18 years.

Exclusion

Exclusion Criteria:

  • Pregnant and lactating females.

  • Patients with liver, renal impairment or any other inflammatory diseases.

  • Patients on TNF-α (tumor necrosis factor- α) or IL-1β (interleukin-1β) antagonists.

Study Design

Total Participants: 80
Treatment Group(s): 1
Primary Treatment: Diosmin and Hesperidin Combination
Phase: 3
Study Start date:
July 18, 2023
Estimated Completion Date:
September 30, 2026

Study Description

Evaluation of the anti inflammatory and antioxidant effects of the flavonoids combination (diosmin and hesperidin) as adjuvant therapy on patients with rheumatoid arthritis.

Clinical and functional assessment of disease activity.

Evaluation of hepatoprotective effect against methotrexate induced liver adverse events.

Connect with a study center

  • Alexandria university hospital

    Alexandria,
    Egypt

    Active - Recruiting

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