Cold Agglutinin Disease Real World Evidence Registry

Inclusion Criteria:

1. Patient aged ≥18 years
2. Patient able to understand the purpose of the study and who (or whose legallyauthorized representative) provided signed and dated informed consent andauthorization to use protected health information in accordance with national andlocal subject privacy regulations
3. Patient with a diagnosis of CAD or CAS as per Investigator judgment based on thediagnosis criteria listed in study protocol

Exclusion Criteria:

1. Patient with mixed warm and cold autoimmune hemolytic anemia, or warm autoimmunehemolytic anemia
2. Patient actively participating in a CAD or CAS interventional clinical trial. After apatient completes participation in said trial, he/she may be eligible for enrollmentin this registry.