The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck

Last updated: January 21, 2025
Sponsor: Royal Marsden NHS Foundation Trust
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Cancer

Human Papilloma Virus (Hpv)

Head And Neck Cancer

Treatment

Molecular Analyses

Clinical Study ID

NCT05808920
CCR 5752
  • Ages > 18
  • All Genders

Study Summary

The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC).

Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Aged over 18

  2. Previous H&N SCC treated with radiotherapy with or without chemotherapy

  3. Local or regionally recurrent, residual, or new primary SCC of the oropharynx, oralcavity, larynx, and hypopharynx

  4. Ability to give informed consent for biological sample collection (molecularanalysis study only)

Exclusion

Exclusion Criteria:

  1. Nasopharyngeal and cutaneous SCC of the H&N

  2. Thyroid, salivary gland, and non-squamous cell H&N cancers

  3. Presence of distant metastasis (M1) or surgically inoperable T4b tumours

Study Design

Total Participants: 400
Treatment Group(s): 1
Primary Treatment: Molecular Analyses
Phase:
Study Start date:
September 08, 2023
Estimated Completion Date:
August 01, 2028

Study Description

The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC).

Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.

The aim of this study is to determine the survival, functional and quality of life outcomes of patients undergoing all salvage surgery for recurrent, residual and new primary head and neck SCC, and to establish the genetic architecture and clonal evolution H&N SCC after previous treatment for radiotherapy cancer.

Connect with a study center

  • Head and Neck Unit, Royal Marsden Hospital

    London, SW3 6JJ
    United Kingdom

    Active - Recruiting

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