The RESCUE Study: Survival and Functional Outcomes Following Salvage Surgery for RESidual or reCurrent sqUamous cEll Carcinoma of the Head and Neck

Last updated: February 9, 2026
Sponsor: Royal Marsden NHS Foundation Trust
Overall Status: Active - Recruiting

Phase

N/A

Condition

Lung Cancer

Nasopharyngeal Cancer

Human Papilloma Virus (Hpv)

Treatment

Molecular Analyses

Clinical Study ID

NCT05808920
CCR 5752
  • Ages > 18
  • All Genders

Study Summary

The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC).

Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Aged over 18

  2. Previous H&N SCC treated with radiotherapy with or without chemotherapy

  3. Local or regionally recurrent, residual, or new primary SCC of the oropharynx, oralcavity, larynx, and hypopharynx

  4. Ability to give informed consent for biological sample collection (molecularanalysis study only)

Exclusion

Exclusion Criteria:

  1. Nasopharyngeal and cutaneous SCC of the H&N

  2. Thyroid, salivary gland, and non-squamous cell H&N cancers

  3. Presence of distant metastasis (M1) or surgically inoperable T4b tumours

Study Design

Total Participants: 400
Treatment Group(s): 1
Primary Treatment: Molecular Analyses
Phase:
Study Start date:
September 08, 2023
Estimated Completion Date:
April 30, 2029

Study Description

The RESCUE study is a combined retrospective and prospective multicentre cohort study investigating the survival and functional outcomes in patients undergoing salvage surgery for recurrent, residual, and new primary head and neck squamous cell carcinoma (SCC).

Additionally, the RESCUE study will contain an exploratory molecular analysis of consenting patients to assess the relationship between cancer genomics, previous radiotherapy, and recurrence in head and neck cancer.

The aim of this study is to determine the survival, functional and quality of life outcomes of patients undergoing all salvage surgery for recurrent, residual and new primary head and neck SCC, and to establish the genetic architecture and clonal evolution H&N SCC after previous treatment for radiotherapy cancer.

Connect with a study center

  • University Hospitals Derby and Burton

    Derby 2651347,
    United Kingdom

    Active - Recruiting

  • NHS Lothian

    Edinburgh 2650225,
    United Kingdom

    Active - Recruiting

  • Western General, Greater Glasgow and Clyde

    Glasgow 2648579,
    United Kingdom

    Active - Recruiting

  • Aintree Hospital

    Liverpool 2644210,
    United Kingdom

    Active - Recruiting

  • Head and Neck Unit, Royal Marsden Hospital

    London, SW3 6JJ
    United Kingdom

    Site Not Available

  • Head and Neck Unit, Royal Marsden Hospital

    London 2643743, SW3 6JJ
    United Kingdom

    Active - Recruiting

  • Northwick Park

    London 2643743,
    United Kingdom

    Active - Recruiting

  • Oxford University Hospital NHS Foundation Trust

    Oxford 2640729,
    United Kingdom

    Active - Recruiting

  • Poole Hospital, University Hospitals Dorset

    Poole 2640101,
    United Kingdom

    Active - Recruiting

  • South Tyneside and Sunderland NHS Foundation Trust

    Sunderland 2636531,
    United Kingdom

    Completed

Map preview placeholder

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.