MS-DETECT: Early Detection of Multiple Sclerosis Progression with MSCopilot® Detect

Inclusion Criteria:

• Adult patients living with RRMS or SPMS, aged 30 to 65

• EDSS score between 2.5 to 6.5 points

• With a disease duration > 5 years

• Clinically stable during the last 3 months before inclusion (no relapses, nodisability progression)

• No change in the DMT* during the last 3 months before inclusion

• Receiving optimal symptomatic treatments at baseline (clinician's judgment)

• Owns a personal smartphone which mobile operating system is above 14 for IOS (iPhone) and 8 for Android included with a good internet connexion

• Able to use a smartphone

• Able to read language in wich the mobile application is available and able tounderstand pictograms.

• Applicable to patients enrolled in France only: affiliated to a social securitysystem.

Exclusion Criteria:

• Medically unstable conditions that may hinder patient's ability to comply with thestudy procedures

• Inability to use a smartphone or MSCopilot® Detect application

• Patient with corrected visual acuity less than 4/10 (Monoyer) or 20/50 (Snellen at 20 feet) or +0,4 (LogMAR)

• Pregnancy and nursing women

• Persons under guardianship or curatorship

• Current drugs or/and alcohol abuse that could influence performance on the tests (clinician's judgment)

• Patients have participated in another clinical study within the previous 30 days ofscreening or are currently participating in another study that, in the opinion ofthe Investigator, might interfere with the patient's full participation in the studyor confound the assessment of the patient or outcome of the study.