Innovative Cognitive and Behavioral Psychotherapy for Cocaine Use Disorder

Last updated: June 7, 2024
Sponsor: Thomas Lehoux
Overall Status: Active - Recruiting

Phase

N/A

Condition

Stimulant Use Disorder

Treatment

Virtual Reality Cue Exposure (VRCE) Therapy for Cocaine Craving - 2 weeks

Pictures-based Cue Exposure (PCE) Therapy for Cocaine Craving - 3 weeks

Memory Focused Cognitive Therapy (MFCT) - 1 week

Clinical Study ID

NCT05833529
22_RIPH2-18
2022-A02440-43
  • Ages > 18
  • All Genders

Study Summary

Cocaine is the 2nd most used illicit substance in Europe and its use implies numerous health complications as well as an annual social cost of 8.7 G d'€. Classical (picture, video, audio, imagery based or in vivo) cue exposure therapy for substance craving (CET), i.e. the irrepressible and non-voluntary desire to use the substance, failed to prove efficacious in treating substance use disorder. Virtual reality cue exposure therapy for substance craving (VRCET), is more immersive, realistic and controllable, and is suggested as being a more efficacious intervention in reducing craving as compared to classical CET.

So far it's still not known, thus the secondary aim of the present randomized and clinical trial is to investigate, whether virtual reality cue exposure is more efficacious, as compared to classical cue exposure, in both eliciting and reducing cocaine craving in a clinical context of CET for cocaine craving. The main study aim to is to investigate whether a VRCET for cocaine craving based cognitivo-behavioral therapy (i.e. VRCET followed by memory focused cognitive therapy) is more efficacious than a behavioural therapy (i.e. classical exposure therapy to craving) in reducing cocaine craving.

To do so, 54 voluntary residential patients in treatment for cocaine use disorder will be recruited from the Universitary Hospital Center of Martinique (CHUM, Martinique, France) and Saint-Esprit Hospital Center (CHSE, Martinique, France) and randomly allocated in either a 3 weeks individual experimental treatment (10 meetings of VRET for cocaine craving followed by 5 meetings of memory focused cognitive therapy) or a 3 weeks individual control treatment (15 meetings of pictures based exposure therapy for cocaine craving). Self-reported measures of retrospective (last 14 days) and in virtuo exposure cocaine craving will be collected at the beginning, after 10 days, after 15 days of treatment and 1 month post. Others secondary subjective, urinary and physiological cocaine use related measures will also be collected.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Adult patients (age greater than or equal to 18),

  • Present the diagnostic criteria for a cocaine use disorder (DSM-5; SCID 5-CV),

  • Be voluntarily hospitalized and engaged in a residential standard treatment forcocaine use disorder at the Universitary Hospital of Martinique or at the HospitalCentre of Saint-Esprit in Martinique,

  • Present a motivation of "action" or "maintenance" of cocaine use cessation (University of Rhode Island Change Assessment Scale),

  • Have been informed of the research,

  • Have given free, informed and express consent,

  • Be affiliated to a social security scheme.

Exclusion

Exclusion Criteria:

  • Present the diagnostic criteria (MINI 5.0.0.; DSM-IV):

  • Current high suicide risk episode,

  • Current psychotic syndrome,

  • Current mania or hypomania episode,

  • Current post-traumatic stress

  • Present significant symptoms of cyberkinetosis in virtual reality exposure (SP-IE),

  • Present another current medical condition at risk of danger or inability to complywith the protocol (e.g. heart problems, blindness or deafness,...),

  • Be placed under legal safeguard, guardianship or curatorship,

  • Patient who refused to participate in the study,

  • Pregnant or breastfeeding women.

Study Design

Total Participants: 54
Treatment Group(s): 3
Primary Treatment: Virtual Reality Cue Exposure (VRCE) Therapy for Cocaine Craving - 2 weeks
Phase:
Study Start date:
May 01, 2023
Estimated Completion Date:
May 31, 2025

Connect with a study center

  • University Hospital Center of Martinique

    Fort-de-France, 97261
    Martinique

    Active - Recruiting

  • Hospital Center of Saint-Esprit (Martinique)

    Saint-Esprit, 97270
    Martinique

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.