Magnesium Injection Ensures Steroid Avoidance During Vaccine, Viremia or Immunocompromise

Last updated: January 23, 2025
Sponsor: Salem Anaesthesia Pain Clinic
Overall Status: Active - Recruiting

Phase

N/A

Condition

Metabolic Disorders

Treatment

Magnesium

Clinical Study ID

NCT05862454
SalemAnes2022 Mg Steroid Avoid
  • Ages 20-99
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Steroid injections are used for interventional pain management. However, their side-effect of immunosuppression may increase the risk of infections. Magnesium is an alternative anti-nociceptive injection that may be used instead of steroids.

Prospective observational study of patients who received magnesium injection for interventional pain therapy, instead of steroid injection. Post-injection data collection includes numerical rating pain score, and sleep quality score. Pain is measured using the numeric pain rating scale. Sleep score is measured using the Likert sleep scale. A change in the pain or sleep scores by 2-points is considered significant.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • adult chronic pain patients

  • previous interventional injection therapy

  • consent for interventional injection therapy

  • good treatment compliance

  • regular sleep diary

  • regular pain diary

  • informed consent for diary review

  • consent for clinical record quality assurance review

Exclusion

Exclusion Criteria:

  • organ insufficiency

  • cognitive disorder

  • inability to provide consent

  • major neuropsychiatric disorder

  • unreliable diary

  • poor treatment compliance

  • previous adverse/allergic reactions to magnesium

Study Design

Total Participants: 150
Treatment Group(s): 1
Primary Treatment: Magnesium
Phase:
Study Start date:
July 02, 2020
Estimated Completion Date:
December 31, 2025

Study Description

Corticosteroid injections are used for interventional pain management. The immunosuppression effect of steroid injection may increase the risk of infections. Magnesium is an alternative anti-nociceptive agent that may be used for interventional pain injection therapy, instead of steroids.

Prospective observational clinical study of pain clinic patients who received magnesium injection for interventional pain therapy, instead of steroid injection. Post-injection data collection includes numerical rating pain score, and sleep quality score. Pain is measured using the numeric pain rating scale. Sleep score is measured using the Likert sleep scale. A change in the pain or sleep scores by 2-points is considered significant. Data analyzed with IBM® SPSS® Statistics 25 (IBM Corp, Armonk, NY); using Student's t-test, ANOVA, Pearson Chi-square test, and regression analysis. P-value <0.05 is considered significant.

Connect with a study center

  • Salem Anaesthesia Pain Clinic

    Surrey, British Columbia V3S 7J1
    Canada

    Active - Recruiting

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