A Switch Study From High-Sodium Oxybate to XYWAV to Evaluate Changes in Blood Pressure in Participants With Narcolepsy

Key Inclusion Criteria:

• Participants must be 18 to 70 years of age inclusive, at the time of signing theinformed consent.

• Participants have a documented diagnosis of Type 1 or Type 2 narcolepsy that meetsInternational Classification of Sleep Disorders (ICSD)-3 or Diagnostic andStatistical Manual of Mental Disorders (DSM)-5 criteria.

• Participants must have been receiving a total dose of high-sodium oxybate (eg,XYREM) of 6 to 9 g/night (inclusive) with twice-nightly dosing for a minimum of 6consecutive weeks prior to screening.

• If currently treated with stimulants and/or alerting agents or other medicationsknown to affect BP, participant must have been taking the same dosing regimen for atleast 2 months prior to screening and agree to take the same dose throughout thestudy.

• If currently taking stable doses of antihypertensive therapies, participant mustmaintain these treatments at the same dose throughout the study unless otherwiseadvised by their medical care

• Participant is male or female. A female participant is eligible to participate ifshe is not pregnant or breastfeeding, if she is a woman of nonchildbearing potentialor is a woman of childbearing potential and using a contraceptive method that ishighly effective.

Key Exclusion Criteria:

• History or presence of any acutely unstable medical condition, behavioral orpsychiatric disorder (including active suicidal ideation), or surgical history thatcould affect the safety of the participant or interfere with study assessments orthe ability of the participant to complete the study based on the judgment of theinvestigator.

• Presence of significant cardiovascular disease or cardiovascular condition that inthe investigator's opinion may jeopardize participant safety in the study, includingscreening ECG results.

• Presence of atrial fibrillation detected on screening electrocardiogram (ECG).

• Presence of resistant hypertension.