Video Assisted Thoracoscopic Surgery (VATS) - Surgical Pleurodesis vs Tube Drainage in Management of Malignant Pleural Effusion (MPE)

Last updated: May 22, 2023
Sponsor: Assiut University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pleural Effusion

Lung Disease

Treatment

Tube Drainage

VATS-Surgical pleurodesis

Clinical Study ID

NCT05872126
AssiutMedicCTS
  • Ages 5-90
  • All Genders

Study Summary

Malignant Pleural Effusion (MPE) is considered to be a common presentation at malignant tumors representing 15% of all cancer cases. It carries a burden on our patients with dyspnea being the most common symptom in most of cases.

Management of symptomatic malignant pleural effusion remains to be a point of debate. Data available from literature shows conflicting results lacking high quality evidence which necsscitates further research work. Options differs to include chemical pleurodesis using medical or surgical talc poudrage or slurry. Surgical intervention with abrasion pleurodesis or pleurectomy using VATS approach has been used in many studies. Using indwelling pleural catheters (IPCs) has also proved comparable efficacy at many clinical trials. In this study we want to help answering this question so that we can add to the current knowledge aiming to offer the best care for those patients

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • 1-patients with symptomatic malignant pleural effusion. 2- symptomatic patients withshortness of breath. 3-Lung can be fully expanded.

Exclusion

Exclusion Criteria:

  1. Patients with non symptomatic malignant pleural effusion
  2. Pleural symphysis with no potentiality for re-expansion
  3. Patients managed surgically through open thoracotomy.
  4. Pleural effusion due to causes other than malignancy
  5. Loculated malignant effusion judged by chest ultrasound
  6. Trapped lung due to malignant pleural effusion assessed by multislice CT chest.,
  7. .Refusal to share the research project and not to sign the consent.

Study Design

Total Participants: 60
Treatment Group(s): 2
Primary Treatment: Tube Drainage
Phase:
Study Start date:
April 01, 2023
Estimated Completion Date:
April 30, 2025

Connect with a study center

  • Assiut university heart hospital

    Assiut, 2112
    Egypt

    Active - Recruiting

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