A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular Disease

Inclusion Criteria:

• Have a body mass index (BMI) ≥35.0 kilogram/square meter (kg/m²).

• Have established cardiovascular (CV) disease with at least 1 of the following:

• prior myocardial infarction

• prior ischemic or hemorrhagic stroke, or

• symptomatic peripheral arterial disease

• Have a history of at least 1 self-reported unsuccessful dietary effort to reducebody weight.

Exclusion Criteria:

• Have had acute myocardial infarction, stroke, coronary revascularization,hospitalization for unstable angina, or hospitalization due to congestive heartfailure within 90 days prior to screening.

• Have taken weight loss drugs, including over-the-counter medications, within 90 daysprior to screening.

• Have a prior or planned surgical treatment of obesity.

• Have a change in body weight greater than 5 kg (11 pounds) within 90 days prior toscreening.

• Have Type 1 diabetes.

• Have family or personal history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia syndrome type 2 (MEN-2)

• Have had pancreatitis.