Evaluation of 2 Synthetic Nitrile Male Condoms Compared to a Standard Latex Male Condom

Inclusion Criteria:

1. Be between the ages of 18 and 45 years (inclusive);

2. Be literate (able to read a newspaper or letter easily);

3. Have been in an exclusive (monogamous) sexual relationship with partner for at least 3 months; and intend to continue to be an exclusive (monogamous) sexual relationshipwith their spouse or partner while participating in this research study;

4. Be sexually active (defined as having at least one vaginal coital act per week);

5. Willing to give informed consent;

6. Willing to complete the male condom coital use reports;

7. Willing to use the study condoms as directed;

8. Agree to use only the study lubricant provided;

9. Agree to only use the study condoms sequentially during time of participation

10. Willing to adhere to the follow-up schedule and all study procedures;

11. Willing to provide research study staff with an address, phone number or otherlocator information while participating in the study;

12. Willing to participate in the study for the duration of 15 condom uses (approximately 3-5 months);

13. Willing to provide photo identification and/or have fingerprint scan to excludeco-enrolment in other research projects;

14. Female partner using hormonal or other non-barrier contraception (e.g. OCs,injectable, implant, IUD, or have had a tubal sterilization) or male partnervasectomised;

15. Agree to return any unopened condoms;

16. Male partner willing to ejaculate during vaginal intercourse;

17. Male partner willing to hold on to the condom ring when withdrawing the erect penisafter sexual intercourse;

18. Agree to not bring study condoms in contact with genital or oral piercing jewelry

19. EAH: Both partners have valid personal email and operable mobile phones;

Exclusion Criteria:

1. Female partner is pregnant or desires to become pregnant during the time of theresearch study;

2. Either partner is known to be HIV positive (based on self report [EAH] or documentedHIV-negative test result within past two months [MRU]);

3. Self-reported history of recurrent sexually transmitted infection (e.g. gonorrhea,syphilis, Chlamydia);

4. Male partner has known erectile or ejaculatory dysfunction;

5. Either partner has genital piercing jewelry, uses genital beading or uses sex toys,drugs, medications or non-study devices that can affect sexual performance;

6. Either partner has known sensitivities or allergies to latex, synthetic nitrile,vaginal/sexual lubricants or lubricants used on condoms;

7. Either partner reports symptoms of STI (EAH) or has observable evidence of STI asdetermined through syndromic diagnosis and vaginal/penile examination (MRU);

8. Either partner is currently participating in another condom study;

9. Either partner is a past or current employee of Essential Access Health, Universityof the Witwatersrand, or Karex;

10. Either partner is a sex worker.