A Study of LY3437943 in Participants With Impaired and Normal Liver Function

Last updated: April 17, 2025
Sponsor: Eli Lilly and Company
Overall Status: Completed

Phase

1

Condition

Primary Biliary Cholangitis

Liver Failure

Liver Disease

Treatment

LY3437943

Clinical Study ID

NCT05916560
18531
J1I-MC-GZBT
  • Ages 18-85
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

The main purpose of this study is to measure how much of LY3437943 gets into the bloodstream and how long it takes the body to eliminate it in participants with mild, moderate and severe impaired liver function compared to healthy participants with normal liver function. The safety and tolerability of LY3437943 will also be evaluated. The study may last up to 9 weeks for each participant including the screening period.

Eligibility Criteria

Inclusion

Inclusion Criteria:

All Participants:

  • Have a body mass index within the range 19.0 to 42.0 kilograms per meter squared (kg/m²), inclusive

  • Healthy or various degrees of hepatic impairment depending on the study group

Exclusion

Exclusion Criteria:

Participants with hepatic impairment:

  • Have or are anticipating an organ transplant within the next 6 months

  • Requires needle evacuation of ascites fluid more than 2 times per month

  • Have had variceal bleeding within 3 months of check-in, unless the participant hasundergone a successful banding procedure; in that case, may check-in from 1 monthafter the banding procedure

Study Design

Total Participants: 43
Treatment Group(s): 1
Primary Treatment: LY3437943
Phase: 1
Study Start date:
July 13, 2023
Estimated Completion Date:
March 02, 2025

Connect with a study center

  • Arizona Clinical Trials - Chandler

    Chandler, Arizona 85225
    United States

    Site Not Available

  • Arizona Clinical Trials- Chandler

    Chandler, Arizona 85225
    United States

    Active - Recruiting

  • Accel Research Sites- Clinical Research Unit

    DeLand, Florida 32720
    United States

    Site Not Available

  • Advanced Pharma Clinical Research

    Miami, Florida 33147-4040
    United States

    Site Not Available

  • American Research Corporation at Texas Liver Institute

    San Antonio, Texas 78215
    United States

    Site Not Available

  • Pinnacle Clinical Research

    San Antonio, Texas 78229
    United States

    Site Not Available

Not the study for you?

Let us help you find the best match. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.