Side Effects of Antibiotics in Bone and Joint Infections

Last updated: December 4, 2024
Sponsor: University Hospital, Tours
Overall Status: Active - Recruiting

Phase

N/A

Condition

Osteomyelitis

Treatment

N/A

Clinical Study ID

NCT05927311
DR230121-PROSEAB
  • Ages > 18
  • All Genders

Study Summary

Treatment for bone and joint infection (BJI) is not standardized, which allows a wide range of antibiotic therapy to potentially be given, most often in high doses over long periods of time. Patients are regularly confronted with the adverse effects of these antibiotics, which can lead to loss of adherence and treatment failure. The frequency, severity and impact on quality of life of the adverse effects of long-term antibiotics will be studied in a cohort followed for one year.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Patient over 18 years of age

  • Microbiologically proven osteoarticular infection with or without material,requiring antibiotic therapy (single or multiple) of 6 weeks or more

  • Oral antibiotic therapy (minimum 4 weeks)

Exclusion

Exclusion Criteria:

  • Opposition to data processing

  • Patient under guardianship or trusteeship

Study Design

Total Participants: 300
Study Start date:
August 11, 2023
Estimated Completion Date:
August 31, 2025

Study Description

Treatment for bone and joint infection is not standardized, which allows a wide range of antibiotic therapy to potentially be given, most often in high doses over long periods of time. Patients are regularly confronted with the adverse effects of these antibiotics, which can lead to loss of adherence and treatment failure. Although patients with BJI receive regular follow-up, the impact of adverse events during treatments lasting more than a month is still poorly developed in the literature.

The frequency, severity and impact on quality of life of the adverse effects of long-term antibiotics will be studied in a cohort followed for one year.

The investigators believe that this study will improve the management of osteoarticular infections through a better understanding of the adverse effects associated with prolonged, high-dose antibiotic therapy, and encourage more multidisciplinary follow-up.

Connect with a study center

  • University Hospital

    Tours, 37044
    France

    Active - Recruiting

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