A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee

Inclusion Criteria:

• Have a body mass index (BMI) ≥27 kilogram/kg/m² at screening.

• Have a history of at least 1 self-reported unsuccessful dietary effort to lose bodyweight.

• Have index knee pain for >12 weeks prior to screening, and presence of index kneepain for >15 days over the previous month.

• Have knee X-ray with moderate radiographic changes (Kellgren-Lawrence Grade 2 or 3)per central reading at screening.

• Currently meets American College of Rheumatology (ACR) Criteria (clinical andradiological) for OA.

Exclusion Criteria:

• Have had steroid joint injections within 90 days of screening.

• Have had other joint injections and procedures within 6 months of screening.

• Have joint disease other than osteoarthritis.

• Have a self-reported or documented change in body weight >5 kg (11 pounds) within 90days prior to screening.

• Have been taking weight loss drugs, including over-the-counter medications, within 90 days prior to screening.

• Have a prior or planned surgical treatment for obesity.

• Have diabetes mellitus.