A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 Diabetes

Inclusion Criteria:

• Have a body mass index (BMI) ≥27 kilogram/square meter (kg/m²)

• Have either

• no T2D with an HbA1c < 6.5% or

• have T2D with an HbA1c ≤ 9.5% and treated with diet and exercise only or withstable doses of up to 3 oral antihyperglycemic medications, with or withoutbasal insulin for at least 90 days before screening.

• Have been diagnosed with chronic kidney disease (CKD).

Exclusion Criteria:

• Have a self-reported change in body weight >5 kilogram (kg) (11 pounds) within 90days before screening.

• Have used in 90 days before the screening any of the following antihyperglycemicclass: Dipeptidyl Peptidase IV (DPP4) inhibitors, amylin analogs, glucagon-likepeptide-RA (GLP-RA), gastric inhibitory polypeptide (GIP)/GIP-1 RA, and short actingor rapid acting insulins or U500 Insulin

• Have a prior or planned surgical treatment for obesity

• Have Type 1 Diabetes (T1D)

• Have acute or chronic hepatitis

• Have a history of malignant disease within 5 years before screening.