RISE: A Remote Study of Insomnia Treatment in Crohn's Disease

Last updated: September 30, 2024
Sponsor: Dartmouth-Hitchcock Medical Center
Overall Status: Active - Recruiting

Phase

N/A

Condition

Insomnia

Treatment

Sleep Education Treatment

Behavioral Treatment

Clinical Study ID

NCT05956158
STUDY02001855
  • Ages > 18
  • All Genders

Study Summary

The purpose of this study is to assess whether the investigators can treat insomnia in people with Crohn's disease, and if insomnia treatment can make other things better, like pain or inflammation.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Mild to moderate CD based on PRO-3 & 50% with objective evidence of active disease

  • Insomnia Severity Index score ≥ 8 and SOL or WASO ≥ 30 minutes

  • Stability of sleep & CD meds for ≥ 3 months

  • Access to internet or cell phone service sufficient for telehealth

Exclusion

Exclusion Criteria:

  • PHQ-9 depression score ≥ 15

  • GAD-7 anxiety score ≥ 15

  • Unstable major psychiatric condition (e.g., bipolar disorder, psychotic disorder)

  • Current alcohol or substance abuse

  • Current opioid use for pain control

  • Current systemic corticosteroid use

  • Current pregnancy or nursing

  • Ileostomy or colostomy

  • Diagnosis of seizure disorder

  • Diagnosis of sleep apnea or positive WatchPAT screen

  • Diagnosis of restless leg syndrome or positive Cambridge-Hopkins RSLq screen

  • Night shift, rotating shift work, or frequent travel outside of time zone

Study Design

Total Participants: 83
Treatment Group(s): 2
Primary Treatment: Sleep Education Treatment
Phase:
Study Start date:
November 28, 2023
Estimated Completion Date:
October 01, 2026

Study Description

People with Crohn's disease often suffer from sleep problems. Long term, sleep problems may lead to more flares of Crohn's disease or other complications. In general, patients with Crohn's disease also report that sleep problems can worsen symptoms of Crohn's disease the next day. In people with other medical problems, research has also shown that having sleep problems can make other things worse, such as pain and inflammation. In this study, the investigators want to understand if they can treat sleep problems in people with Crohn's disease, and what else might improve if sleep gets better. If this study is successful, it will help the investigators understand more about how to treat insomnia in people with Crohn's disease and how sleep impacts pain and inflammation. Long term, this information will be helpful in understanding how best to take care of people with Crohn's disease.

Connect with a study center

  • Dartmouth-Hitchcock Medical Center

    Lebanon, New Hampshire 03756
    United States

    Active - Recruiting

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