Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity

Last updated: August 16, 2023
Sponsor: Henri Mondor University Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Brain Cancer

Brain Tumor

Spinocerebellar Disorders

Treatment

EMG in wrist flexor-pronators and extensor-supinators

Clinical Study ID

NCT05998486
ARM-Tremor
  • Ages 18-100
  • All Genders

Study Summary

Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to characterize resting tremor and discriminate it from cerebellar tremor (CT) based on the frequency spectrum of the EMG signal.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • patient who performed surface EMG recordings of wrist flexor-pronators andextensor-supinators in Laboratories;
  • diagnosis of Parkinson's disease or cerebellar tremor.

Exclusion

Exclusion Criteria:

  • Botulinium toxin injection in upper limb during a delay of 3 months before surface EMGrecordings;
  • Levodopa drugs administrated during a delay of 12 hours before surface EMG recordings;
  • Tremor-favour drugs administrated during a delay of 30 days before surface EMGrecordings;
  • Presence of an other neurologic disease or of any disease associated with motordisorders in upper limb.

Study Design

Total Participants: 80
Treatment Group(s): 1
Primary Treatment: EMG in wrist flexor-pronators and extensor-supinators
Phase:
Study Start date:
April 03, 2023
Estimated Completion Date:
December 31, 2023

Study Description

This retrospective study analyzed surface EMG recordings of wrist flexor-pronators and extensor-supinators from patients with PD or CT bilaterally in five 10-second conditions: rest with contralateral motor distraction, symmetrical arms extended forward posture with hands pronated, semi-pronation, supination, and elbows flexed with hands pronated. The rhythmicity index (RI) is calculated from the ratio of the area of the maximum power peak to the total area of the spectrum between 1.5-12Hz.

Connect with a study center

  • Laboratoire Analyse et Restauration du Mouvement

    Créteil,
    France

    Active - Recruiting

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