A Dose Escalation and Dose Expansion Study of Intratumoral ONM-501 Alone and in Combination With Cemiplimab in Patients With Advanced Solid Tumors and Lymphomas.

Inclusion Criteria:

1. Ability to understand and willingness to sign written informed consent beforeperformance of any study procedures

2. Age ≥ 18 years

3. Participants with solid tumors or lymphomas, confirmed by available histopathologyrecords or current biopsy, that are advanced, nonresectable, or recurrent andprogressing since last antitumor therapy, and for which no alternative standardtherapy exists.

4. Participants must have a minimum of one injectable and measurable lesion.

5. Participants with prior Hepatitis B or C are eligible if they have adequate liverfunction

6. Participants with human immunodeficiency virus (HIV) are eligible if on establishedHAART for a minimum of 4 weeks prior to enrollment, have an HIV viral load <400copies/mL, and have CD4+ T-cell (CD4+) counts ≥ 350 cells/uL

7. Adequate bone marrow function:

8. Adequate liver function

Exclusion Criteria: Patients will be excluded from this study if they meet any of the following criteria (Part 1a and Part 1b).

1. Other malignancy active within the previous 2 years except for basal or squamouscell skin cancer, superficial bladder cancer, or carcinoma in situ of the cervix orbreast that has completed curative therapy.

2. Major surgery within 4 weeks before the first dose of study drug.

3. Brain metastases that are untreated or in the posterior fossa or involve themeninges. Participants with stable or previously treated progressing brainmetastases (except in the posterior fossa or involving the meninges) may bepermitted in a case-by-case basis at the Sponsor's discretion.

4. Prolongation of corrected QT (QTc) interval to >470 millisecond (ms) for males andfemales when electrolytes balance is normal.

5. Females who are breastfeeding or pregnant at screening or baseline

6. Females of childbearing potential that refuse to use a highly effective method ofcontraception.

7. Has uncontrolled or poorly controlled hypertension as defined by a sustained BP > 9.Has received prior investigational therapy within 5 half-lives of the agent or 4weeks before the first administration of study drug, whichever is shorter.

8. Has had any major cardiovascular event within 6 months prior to study drug 10. Hasknown hypersensitivity to any component in the formulation of ONM-501

9. Has an active infection requiring systemic treatment

10. Is participating in another therapeutic clinical trial

Additional Exclusion Criteria for ONM-501 in Combination with cemiplimab (Part 1b)

1. Has known hypersensitivity to any component in the formulation of cemiplimab

2. Has any active or recent history of a known or suspected autoimmune disease orrecent history of a syndrome that required systemic corticosteroids (>10 mg dailyprednisone equivalent)

3. Has a condition requiring systemic treatment with corticosteroids