A Study of BMS-986466 With Adagrasib With or Without Cetuximab in Participants With Kirsten Rat Sarcoma Virus Glycine 12 to Cysteine (KRAS G12C)-Mutant Solid Tumors

Inclusion Criteria:

Key Inclusion Criteria:

Part 1:

• Individuals with a confirmed diagnosis of advanced KRAS G12C mutant NSCLC, CRC, PDACand BTC that has spread to other parts of the body and cannot be removed surgically,may or may not have received previous treatment with KRAS G12C inhibitors.

• For NSCLC and CRC: Individuals must have a documented KRAS G12C mutation status fromNYS or FDA approved/cleared or CE marked test or, when such result is not available,positive KRAS G12C mutation status should be confirmed by a central laboratory inblood sample collected at the time of screening.

• For PDAC and BTC: Participants must have a documented KRAS G12Cmutation from NYS orFDA-approved/cleared, or CE-marked test and blood samples will be collected only forretrospective testing.

• Are relapsed or refractory to available standard of care treatments.

Part 2:

• Individuals with a confirmed diagnosis of advanced KRAS G12C-mutant NSCLC (Part 2A)or CRC (Part 2B) that has spread to other parts of the body and cannot be removedsurgically and have not received previous treatment with KRAS inhibitors.

• Individuals must have a documented KRAS G12C mutation from FDA or NYS approved/cleared or CE marked test or, when such result is not available, positive KRAS G12Cmutation status should be confirmed by a central laboratory in blood sample and /ortumor samples collected at the time of screening or from archival biopsies (lessthan 1 year old).

• Have failed or disease recurrence or are not able to tolerate after at least 1pervious line of therapy.

Key Exclusion Criteria:

• Have tumors with known BARF V600X, PTPN11 or KRASQ61X mutations.

• Have or any significant heart disease or condition.

• Receiving any medications that are substrate of CYP3A4 or inducers and/ orinhibitors

Note: Other protocol-defined inclusion/exclusion criteria apply.