CABG Based on CT-FFR Versus Conventional Coronary Angiography

Last updated: July 2, 2024
Sponsor: Myongji Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Chest Pain

Hypercholesterolemia

Coronary Artery Disease

Treatment

Coronary artery bypass grafting based on cardiac computed tomography-derived fractional flow reserve.

Coronary artery bypass grafting based on conventional coronary angiography

Clinical Study ID

NCT06028165
MyongjiH
  • Ages 40-80
  • All Genders

Study Summary

The aims of study are (1) to compare early and 1-year graft patency rates in patients who underwent coronary artery bypass grafting (CABG) based on conventional coronary angiography(CAG) versus cardiac computed tomography(CT)-derived fractional flow reserve(FFR), and (2) to demonstrate difference in clinical outcomes between the 2 groups.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • age equal or more than 40

  • age equal or less than 80

  • patients who undergo coronary artery bypass grafting due to multi-vessel coronaryartery disease

  • patients who agree to the enrollment

Exclusion

Exclusion Criteria:

  • Patients with heart failure (left ventricular ejection fraction < 25%)

  • patients who have intractable ventricular arrhythmia

  • patients who has been treated for cancer

  • patients who has infectious disease

  • patients who are planned to undergo combined cardiac surgery

  • patients who has medical co-morbidity with expected survival less than 1 year

  • patients with a history of previous cardiac surgery

  • Patients with chronic renal failure requiring dialysis

  • patients who undergo emergency operation

Study Design

Total Participants: 96
Treatment Group(s): 2
Primary Treatment: Coronary artery bypass grafting based on cardiac computed tomography-derived fractional flow reserve.
Phase:
Study Start date:
October 20, 2023
Estimated Completion Date:
October 01, 2025

Study Description

The CABG-COREA trial is designed as a randomized, controlled trial to recruit 96 patients who undergo coronary artery bypass grafting. Patients were randomized by use of a randomization table. Coronary arteries are revascularized based on conventional coronary angiography (quantitative coronary angiography) or cardiac computed tomography-derived fractional flow reserve according to the randomization result.

The primary end point is to evaluate early and 1-year postoperative graft patency. The secondary end points are overall survival, freedom from cardiac death and freedom from MACCE(major adverse cardiac or cerebrovascular events).

Connect with a study center

  • Myongji Hospital

    Goyang-si, Gyeonggi-do
    Korea, Republic of

    Active - Recruiting

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