Study of GS-0272 in Participants With Rheumatoid Arthritis

Key Inclusion Criteria:

• Age limit for the Republic of Korea for male or nonpregnant female is between 19 and 75 years of age.

Part A (Rheumatoid Arthritis (RA) Cohorts)-Specific Inclusion Criteria:

• Diagnosis of RA at least 3 months prior to screening fulfilling the 2010 AmericanCollege of Rheumatology (ACR)/European League Against Rheumatism (EULAR)classification criteria.

• Ongoing treatment with 1 or 2 conventional synthetic disease-modifying antirheumaticdrugs (csDMARDs) for at least 12 weeks prior to the first dose of study drug, with astable dose for at least 4 weeks prior to the first dose of study drug, as follows:

• Individuals must not be on a biologic disease-modifying antirheumatic drugs (bDMARD)/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) at Day 1or during the study and must discontinue b/tsDMARD use for at least 4 weeks (withthe exception of rituximab, which must be discontinued for at least 16 weeks) priorto the first dose of study drug.

Part B (Active RA Cohort)-Specific Inclusion Criteria:

• Participant is seropositive as demonstrated by a positive anti-cyclic citrullinatedpeptide (anti-CCP) antibody and/or positive rheumatoid factor at screening.

• Participant has an elevated high-sensitivity C-reactive protein (hsCRP) greater thanupper limit of normal (ULN).

• Participant has 6 or more swollen and 6 or more tender joints as assessed on theSJC66/TJC68. Distal interphalangeal joints will not be counted towards the 6 jointeligibility.

• Participant has had inadequate response or intolerance to at least 1 but not morethan 3 bDMARD/tsDMARD therapeutics with no more than 2 MOAs. A lack of response isdefined as documented continued or recurrent disease activity after at least 12weeks of treatment of RA.

Key Exclusion Criteria:

• Meet any of the protocol-specified infection criteria (hepatitis C, Hepatitis B,HIV, tuberculosis, others).

• Inadequate response or intolerance to more than 3 bDMARDs/tsDMARDs with more than 2MOAs.

Note: Other protocol defined Inclusion/Exclusion criteria may apply.