GTP Regimen in the Treatment of Refractory/Recurrent HLH

Inclusion Criteria:

1. Male and female patients ≥1 month of age with HLH
2. Definitive diagnosis of HLH: meets the molecular diagnosis of pHLH or has a familyhistory of HLH, or meets at least 5 of the 8 diagnostic criteria of HLH-2004.
3. The investigators assessed the presence of refractory/recurrent HLH disease. Patientsmust meet one of the following criteria assessed by the investigator:

• Previous conventional HLH treatment did not respond.
• The patients were not satisfied with the efficacy of conventional HLH treatmentor their condition worsened.
• HLH reactivation occurs. Reactivation is defined as: worsening of two or more HLHclinical and laboratory criteria (after initial remission).

4. According to the researchers, the expected survival was more than 2 weeks.
5. The informed consent is signed by the patient or his legal guardian (patients under 18years), or by the patient's legally authorized representative.
6. Women who are fertile are willing to use a highly effective contraceptive method fromthe start of the study until 6 months after the end of the last course of treatment.

Exclusion Criteria:

1. There is active mycobacterium, histoplasma capsulatus, Salmonella, or leishmaniainfection.
2. There is uncontrolled active gastrointestinal bleeding.
3. The investigator believes that there are any serious comorbidities or any otherconditions that make the patient unsuitable for treatment.
4. A history of hypersensitivity or hypersensitivity to any component of the drug in thestudy protocol, such as polysorbate.
5. Had received the BCG vaccine within 12 weeks prior to screening.
6. Have received live or attenuated vaccine (except BCG) within 4 weeks prior toscreening.
7. Pregnancy patients.
8. Within 4 weeks prior to enrollment in this study, another concurrent clinicalintervention study was enrolled.
9. There is any condition or circumstance that the investigator believes may cause thepatient to be unable to complete the study or to comply with study procedures orrequirements.