A Study of Eltrekibart (LY3041658) in Adult Participants With Moderate to Severe Hidradenitis Suppurativa

Last updated: April 17, 2025
Sponsor: Eli Lilly and Company
Overall Status: Active - Recruiting

Phase

2

Condition

Acne Inversa

Hidradenitis Suppurativa

Scalp Disorders

Treatment

Eltrekibart

Placebo

Clinical Study ID

NCT06046729
18518
2023-505608-43-00
U1111-1292-6255
I7P-MC-DSAF
  • Ages 18-75
  • All Genders

Study Summary

This study aims to find the appropriately safe and effective dose and dosing frequency for eltrekibart in adults with moderate-to-severe hidradenitis suppurativa (HS) for further clinical development. The study will last approximately 62 weeks and may include up to 31 visits.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Have a diagnosis of HS for at least 12 months.

  • Have HS lesions in at least 2 distinct anatomical regions. At least 1 of the lesionsmust be at least Hurley Stage II or III.

  • Have an (abscess plus inflammatory nodule) count of at least 5.

  • Agree to use topical antiseptics daily.

  • Had an inadequate response or intolerance to a 28-day course of oral antibiotics.

Exclusion

Exclusion Criteria:

  • Have more than 20 draining fistulae.

  • Have had surgical treatment for HS in the last 4 weeks before randomization.

  • Have an active skin disease or condition, that could interfere with the assessmentof HS.

  • Have a current or recent acute, active infection.

  • Are immunocompromised.

  • Have a history of chronic alcohol abuse, IV drug abuse, or other illicit drug abusewithin 1 year before screening.

Study Design

Total Participants: 350
Treatment Group(s): 2
Primary Treatment: Eltrekibart
Phase: 2
Study Start date:
October 23, 2023
Estimated Completion Date:
July 31, 2026

Connect with a study center

  • East Sydney Doctors

    Darlinghurst, New South Wales 2010
    Australia

    Active - Recruiting

  • Westmead Hospital

    Westmead, New South Wales 2145
    Australia

    Active - Recruiting

  • Sunshine Coast University Hospital

    Birtinya, Queensland 4575
    Australia

    Active - Recruiting

  • Sinclair Dermatology - East Melbourne

    East Melbourne, Victoria 3002
    Australia

    Active - Recruiting

  • Alfred Hospital

    Melbourne, Victoria 3004
    Australia

    Active - Recruiting

  • Fremantle Dermatology

    Fremantle, Western Australia 6160
    Australia

    Active - Recruiting

  • Holdsworth House Medical Practice

    Sydney, 2010
    Australia

    Active - Recruiting

  • Beacon Dermatology

    Calgary, Alberta T3E 0B2
    Canada

    Active - Recruiting

  • Alberta Dermasurgery Centre

    Edmonton, Alberta T6G 1C3
    Canada

    Active - Recruiting

  • Wiseman Dermatology Research Inc.

    Winnipeg, Manitoba R3M 3Z4
    Canada

    Active - Recruiting

  • Brunswick Dermatology Center

    Fredericton, New Brunswick E3B 1G9
    Canada

    Active - Recruiting

  • Simcoderm Medical & Surgical Dermatology Centre

    Barrie, Ontario L4M 7G1
    Canada

    Active - Recruiting

  • DermEffects - Probity - PPDS

    London, Ontario N6H 5L5
    Canada

    Active - Recruiting

  • Center de Recherche St Louis

    Quebec City, Quebec G1W 4R4
    Canada

    Active - Recruiting

  • Hautklinik Erlangen

    Erlangen, Bayern 91054
    Germany

    Active - Recruiting

  • Hautarztpraxis Mahlow

    Blankenfelde-Mahlow, Brandenburg 15827
    Germany

    Active - Recruiting

  • Universitätsklinikum Frankfurt

    Frankfurt am Main, Hessen 60596
    Germany

    Active - Recruiting

  • Universitaetsklinikum der Ruhr-Universitaet Bochum (UKRUB) - St. Josef-Hospital

    Bochum, Nordrhein-Westfalen 44791
    Germany

    Active - Recruiting

  • Universitätsklinikum Bonn

    Bonn, Nordrhein-Westfalen 53127
    Germany

    Active - Recruiting

  • Universitätsklinikum Münster - Albert Schweitzer Campus

    Muenster, Westfalen 48149
    Germany

    Active - Recruiting

  • Hautzentrum Friedrichshain - Dermatologie

    Berlin, 10247
    Germany

    Active - Recruiting

  • Universitaetsklinikum Hamburg-Eppendorf

    Hamburg, 20251
    Germany

    Site Not Available

  • Hospital of Venereal and Skin Diseases A.Syggros

    Athens, Attiki 16121
    Greece

    Active - Recruiting

  • University General Hospital of Heraklion Loc. 1

    Heraklion, Irakleío 711 10
    Greece

    Active - Recruiting

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki, Thessaloníki 56429
    Greece

    Active - Recruiting

  • University General Hospital of Heraklion

    Heraklion, 711 10
    Greece

    Site Not Available

  • Cityclinic Przychodnia Lekarsko Psychologiczna Matusiak Spółka Partnerska

    Wroclaw, Dolnoslaskie 50-566
    Poland

    Active - Recruiting

  • Wro Medica

    Wroclaw, Dolnoslaskie 51-685
    Poland

    Active - Recruiting

  • Dermoklinika-Centrum Medyczne s.c

    Lodz, Lodzkie 90-436
    Poland

    Active - Recruiting

  • Dermoklinika-Centrum Medyczne s.c

    Łódź, Lodzkie 90-436
    Poland

    Site Not Available

  • Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji

    Warszawa, Mazowieckie 02-507
    Poland

    Active - Recruiting

  • Uniwersyteckie Centrum Kliniczne

    Gdansk, Pomorskie 80-214
    Poland

    Active - Recruiting

  • Klinika Badawcza Centrum Badan Klinicznych Wojciech Brzezicki

    Malbork, Pomorskie 82-200
    Poland

    Active - Recruiting

  • Centrum Medyczne Pratia Katowice

    Katowice, Śląskie 40-081
    Poland

    Active - Recruiting

  • Medical Dermatology Specialists

    Phoenix, Arizona 85006
    United States

    Active - Recruiting

  • Saguaro Dermatology Associates, LLC - Probity - PPDS

    Phoenix, Arizona 85008
    United States

    Active - Recruiting

  • Arkansas Research Trials, LLC

    North Little Rock, Arkansas 72117
    United States

    Active - Recruiting

  • Northwest Arkansas Clinical Trials Center

    Rogers, Arkansas 72758
    United States

    Active - Recruiting

  • First OC Dermatology Research Inc

    Fountain Valley, California 92708
    United States

    Active - Recruiting

  • Center For Dermatology Clinical Research, Inc.

    Fremont, California 94538
    United States

    Active - Recruiting

  • Dermatology Research Associates

    Los Angeles, California 90045
    United States

    Active - Recruiting

  • Dermatology Institute and Skin Care Center

    Santa Monica, California 90404
    United States

    Active - Recruiting

  • University of Connecticut

    Farmington, Connecticut 06032
    United States

    Active - Recruiting

  • Florida Academic Dermatology Centers

    Coral Gables, Florida 33134
    United States

    Site Not Available

  • Direct Helpers Research Center

    Hialeah, Florida 33012
    United States

    Active - Recruiting

  • GSI Clinical Research, LLC

    Margate, Florida 33063
    United States

    Site Not Available

  • Skin Research of South Florida

    Miami, Florida 33173-1407
    United States

    Active - Recruiting

  • University of Miami

    Miami, Florida 33125
    United States

    Active - Recruiting

  • Olympian Clinical Research

    Saint Petersburg, Florida 33709
    United States

    Site Not Available

  • Alliance Clinical Research of Tampa

    Tampa, Florida 33615
    United States

    Active - Recruiting

  • Alliance Clinical Research of Tampa Loc. 1

    Tampa, Florida 33615
    United States

    Active - Recruiting

  • ForCare Clinical Research

    Tampa, Florida 33613-1244
    United States

    Active - Recruiting

  • Olympian Clinical Research

    Tampa, Florida 33615
    United States

    Active - Recruiting

  • Advanced Medical Research, PC

    Sandy Springs, Georgia 30328
    United States

    Active - Recruiting

  • NorthShore Medical Group Dermatology - Skokie

    Skokie, Illinois 60077-1049
    United States

    Active - Recruiting

  • Dawes Fretzin Clinical Research Group, LLC

    Indianapolis, Indiana 46250
    United States

    Active - Recruiting

  • Equity Medical - Bowling Green

    Bowling Green, Kentucky 42104
    United States

    Active - Recruiting

  • Derm Research LLC

    Louisville, Kentucky 40217
    United States

    Site Not Available

  • Care Access-Marriottsville

    Marriottsville, Maryland 21104
    United States

    Site Not Available

  • Beth Israel Deaconess Medical Center

    Boston, Massachusetts 02215
    United States

    Active - Recruiting

  • Revival Research Institute - Troy

    Troy, Michigan 48084
    United States

    Active - Recruiting

  • Washington University School of Medicine

    Saint Louis, Missouri 63110
    United States

    Active - Recruiting

  • Skin Specialists, P.C

    Omaha, Nebraska 68144
    United States

    Active - Recruiting

  • ActivMed Practices & Research, Inc.

    Portsmouth, New Hampshire 03801
    United States

    Active - Recruiting

  • ActivMed Practices & Research, Inc. Loc. 5

    Portsmouth, New Hampshire 03801
    United States

    Active - Recruiting

  • Darst Dermatology

    Charlotte, North Carolina 28277-8014
    United States

    Active - Recruiting

  • Dermatology Specialists of Charlotte

    Charlotte, North Carolina 28277
    United States

    Active - Recruiting

  • Duke University Medical Center

    Durham, North Carolina 27710-3038
    United States

    Active - Recruiting

  • University Hospitals Cleveland Medical Center

    Cleveland, Ohio 44106
    United States

    Active - Recruiting

  • Apex Clinical Research Center

    Mayfield Heights, Ohio 44124
    United States

    Active - Recruiting

  • DermDox Centers for Dermatology

    Camp Hill, Pennsylvania 17011
    United States

    Active - Recruiting

  • DermDox Centers for Dermatology Loc. 17

    Camp Hill, Pennsylvania 17011
    United States

    Active - Recruiting

  • DermDox Dermatology Centers

    Sugarloaf, Pennsylvania 18249
    United States

    Active - Recruiting

  • Medical University of South Carolina

    Charleston, South Carolina 29425
    United States

    Active - Recruiting

  • Columbia Dermatology & Aesthetics

    Columbia, South Carolina 29212-8623
    United States

    Active - Recruiting

  • International Clinical Research - Tennessee (IC Research)

    Murfreesboro, Tennessee 37130
    United States

    Active - Recruiting

  • International Clinical Research - Tennessee LLC

    Murfreesboro, Tennessee 37130
    United States

    Active - Recruiting

  • International Clinical Research - Tennessee LLC Research)

    Murfreesboro, Tennessee 37130
    United States

    Active - Recruiting

  • Advanced Research Experts

    Nashville, Tennessee 37211
    United States

    Active - Recruiting

  • Modern Research Associates

    Dallas, Texas 75231
    United States

    Active - Recruiting

  • North Texas Clinical Research

    Frisco, Texas 75034
    United States

    Active - Recruiting

  • Jordan Valley Dermatology Center

    South Jordan, Utah 84095
    United States

    Active - Recruiting

  • Dermatology Specialists of Spokane

    Spokane, Washington 99202-1332
    United States

    Active - Recruiting

  • Medical College of Wisconsin

    Milwaukee, Wisconsin 53226
    United States

    Active - Recruiting

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