A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities

Inclusion Criteria:

• Have a Body Mass Index (BMI) of ≥30 kilogram/square meter (kg/m²) or ≥27 kg/m² andpreviously diagnosed with at least 1 of the following weight related comorbidities:

• Hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease

• Have a history of at least 1 self-reported unsuccessful dietary effort to lose bodyweight (BW)

Exclusion Criteria:

• Have Type 1 Diabetes (T1D) or Type 2 Diabetes (T2D), a history of ketoacidosis, orhyperosmolar state or coma.

• Have a self-reported change in BW>5 kilogram (kg) within 3 months prior to screening

• Have a prior or planned surgical treatment for obesity, excluding liposuction orabdominoplasty if performed >1 year prior to screening.

• Have a history of chronic or acute pancreatitis

• Have any of the following cardiovascular conditions within 3 months prior to week 0.

• Acute myocardial infarction, cerebrovascular accident (stroke), unstableangina, and hospitalization due to congestive heart failure (CHF)

• family or personal history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia syndrome type 2 (MEN-2)

• History of significant active or unstable major depressive disorder (MDD) or othersevere psychiatric disorder within the last 2 years

• Any lifetime history of a suicide attempt