A Study of JNJ-77242113 in Participants With Moderately to Severely Active Ulcerative Colitis

Inclusion Criteria:

• Signed informed consent form 18 years of age or older

• Documented diagnosis of ulcerative colitis (UC) of at least 12 weeks prior toscreening

• Moderately to severely active UC as per the modified Mayo score

• Demonstrated inadequate response to or intolerance of conventional therapy and/oradvanced therapy as defined in the protocol

Exclusion Criteria:

• Participants with current or prior diagnosis of fulminant colitis and/or toxicmegacolon

• UC limited to rectum only or to less than (<) 15 centimeters (cm) of colon

• Presence of a stoma

• Presence or history of fistula

• History of extensive colonic resection (example, <30 cm of colon remaining)

• Diagnosis of indeterminate colitis, microscopic colitis, ischemic colitis, Crohn'scolitis or clinical findings suggestive of Crohn's disease