PRCT002 PRostate Cancer Treatment With the AQUABEAM Robotic System

Inclusion Criteria:

• Clinical Stage ≤ T2c

• PSA ≤ 20 ng/ml

• Prostate volume ≥ 30 ml

• Grade Group (GG) 1 or 2: If GG 1: ≥ 3 cores positive for cancer. Note, multiplepositive from any MRI targeted lesion will be considered as a single positive core.

Exclusion Criteria:

• Any prior or current treatment for prostate cancer, including but not limited tosurgery, radiation therapy (external or brachytherapy), tissue ablation orchemotherapy.

• Patients with previous surgical or minimally invasive treatment of benign prostatichyperplasia within the prior 12 months.

• Radiographically suspicious lymph node involvement confirmed with biopsy or PETscan.

• Evidence of bone metastasis.

• Evidence of extracapsular involvement.

• Evidence of seminal vesicle invasion on DRE or MRI read as "definite", "probable" or "consistent with"

• Any condition or history of illness or surgery that may pose an additional risk tomen undergoing the Aquablation procedure.