BradycArdia paCemaKer With AV Interval Modulation for Blood prEssure treAtmenT

Inclusion Criteria:

1. Patient has or is indicated for a dual-chamber pacemaker. Visit 1 can be performedwithin 30 days prior to a planned implant of a Medtronic Astra/Azure dual-chamberpacemaker system or at any time thereafter

2. On a stable antihypertension treatment regimen with at least 1 class ofantihypertensive drug

3. Office SBP ≥135 mmHg and <180 mmHg

4. Average 24-Hour aSBP ≥130 mmHg and <170 mmHg

Exclusion Criteria:

1. LVEF <50%

2. NYHA Class III-IV

3. History of cerebrovascular accident (CVA) or transient ischemic attack (TIA) within 6 months

4. Myocardial infarction (MI) within 3 months

5. Prior percutaneous or surgical coronary, carotid, or endovascular interventionwithin 3 months

6. Permanent atrial fibrillation

7. Mitral valve regurgitation greater than or equal to grade 3

8. Aortic stenosis with a valve area less than 1.5 cm2

9. Has an active or prior device-based anti-hypertensive treatment (e.g., renaldenervation procedure, baroreflex activation therapy)

10. Has an existing active cardiac device or neurostimulator other than the recentAstra/Azure pacemaker implant