The Effects of Time Points to Cease Parenteral Nutrition and IGF-1 on Very Low Birth Weight Infants

Last updated: October 4, 2023
Sponsor: Peking University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Williams Syndrome

Treatment

(enteral feeding volume/ total fluid volume)*100%

Clinical Study ID

NCT06071403
IRB00001052-23093
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

This study aims to estimate short-term and long-term effects of time points to cease parenteral nutrition on very preterm infants, such as growth; to estimate the role of insulin-like growth factor 1 in the growth.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  1. Infants with a birth weight less than 1500 grams
  2. Infants admitted within 72 hours after birth
  3. Infants born from July 1, 2023, to June 30, 2024
  4. Written informed consent from parents or guardians

Exclusion

Exclusion Criteria:

  1. Infants with congenital abnormality
  2. Infants surviving <7 days after birth

Study Design

Total Participants: 416
Treatment Group(s): 1
Primary Treatment: (enteral feeding volume/ total fluid volume)*100%
Phase:
Study Start date:
July 01, 2023
Estimated Completion Date:
September 30, 2026

Study Description

At present, it is unclear when to cease parenteral nutrition, the effects of cessation times on preterm infants' growth, and whether insulin-like growth factor 1 (IGF-1) has a mediation effect in the procedure that nutrients regulate the growth in preterm infants.

Therefore, a prospective cohort study was designed with the aims:

  1. to estimate the association between the time to cease parenteral nutrition and the growth in very low birth weight;

  2. to investigate the relationship between nutrient volume in parenteral nutrition and growth in very low birth weight;

  3. to analyze the IGF-1 mediation effect between nutrient volume and growth regulations.

Connect with a study center

  • Wei Guo

    Xingtai, He Bei
    China

    Active - Recruiting

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