Study of KITE-197 in Participants With Relapsed or Refractory Large B-cell Lymphoma

Key Inclusion Criteria:

• Relapsed or Refractory Large B-cell Lymphoma

• At least 1 measurable lesion

• Adequate organ and bone marrow function

Key Exclusion Criteria:

• History of malignancy other than nonmelanoma skin cancer or carcinoma in situ (eg,cervix, bladder, breast) unless disease free for at least 2 years

• History of Richter's transformation of chronic leukemic lymphoma

• History of allogenic stem cell transplant (SCT)

• Autologous SCT within 6 weeks of planned KITE-197 infusion

• Prior CD19 targeted antibody, such as tafasitamab and loncastuximab with theexception of individuals who have previously achieved an objective response to suchtherapy and their tumor expresses CD19 by International Council for Harmonisation ofTechnical Requirements for Pharmaceuticals for Human Use (IHC) at the time ofscreening. Individuals who meet these criteria may be eligible

• Prior treatment with bendamustine within 6 months of enrollment

• Prior CAR therapy or other genetically modified cell therapy

• Presence or suspicion of fungal, bacterial, viral, or other infection that isuncontrolled or requiring IV antimicrobials for management

• History of HIV infection or acute or chronic active hepatitis B or C infection

• History or presence of a clinically significant central nervous system (CNS)disorder Note: Prior or active CNS involvement by lymphoma is not an exclusioncriterion.

• History of myocardial infarction, cardiac angioplasty or stenting, unstable angina,New York Heart Association Class II or greater congestive heart failure, or otherclinically significant cardiac disease within 12 months before enrollment

• Presence of primary immunodeficiency

• History of autoimmune disease (eg, Crohn's disease, rheumatoid arthritis, systemiclupus) resulting in end organ injury or requiring systemicimmunosuppression/systemic disease modifying agents within the last 2 years

• History of symptomatic deep vein thrombosis (DVT) or pulmonary embolism within 3months before enrollment. Catheter induced DVT which has been treated for at least 6weeks prior to enrollment is permitted

• Females of childbearing potential who are pregnant or breastfeeding because of thepotentially dangerous effects of the preparative chemotherapy on the fetus or infant

Note: Other protocol defined Inclusion/Exclusion criteria may apply.