Detecting Absence Seizures Using Hyperventilation and Eye Movement Recordings

Last updated: October 13, 2025
Sponsor: Eysz, Inc.
Overall Status: Completed

Phase

N/A

Condition

Seizure Disorders (Pediatric)

Epilepsy (Pediatric)

Seizure Disorders

Treatment

Eysz Hyperventilation Recorder

Clinical Study ID

NCT06093490
1R43NS129363
1R43NS129363
  • Ages 4-12
  • All Genders

Study Summary

This study is being done to find out if a smartphone app can identify absence seizures. Children who have a history of absence seizures, as well as children without any seizure history, will be testing out the app. If participating the child will be guided through hyperventilation, an activity that asks the child to take quick, deep breaths. The app will record video of the child's face and sounds they make during hyperventilation. Hyperventilation is a safe and established technique frequently used during EEG (electroencephalogram) to encourage seizure occurrence. The App will be used during a regularly scheduled EEG.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • typical absence seizure during use of the Eysz Hyperventilation Recorder or Control

Exclusion

Exclusion Criteria:

  • Other seizure type besides typical absence seizure during use of the EyszHyperventilation Recorder

  • subclinical seizure activity

  • inability to participate with study procedures

  • contraindications to hyperventilation including history of subarachnoid hemorrhage,sickle cell anemia, recent cerebrovascular accident or myocardial infarction,significant cardiopulmonary disease, active asthma, known aneurysm, known moyamoyadisease, or pregnancy.

  • People who have a history of generalized tonic clonic convulsions (GTCs) provoked byhyperventilation

Study Design

Total Participants: 65
Treatment Group(s): 1
Primary Treatment: Eysz Hyperventilation Recorder
Phase:
Study Start date:
December 01, 2023
Estimated Completion Date:
July 30, 2025

Study Description

This observational study focuses on validating the use of the Eysz mHealth App - a smartphone-based tool for guided Hyperventilation (HV) and data collection - to aid clinicians in identifying absence seizures in people at risk for childhood absence epilepsy (CAE). The Eysz mHealth app will guide users through HV via interactive graphics while capturing audio and video data using smartphone sensors (e.g., camera, microphone) from which eye movements, facial biometrics/ expressions, number and length of exhales will be extracted.

The goal of this observational study is to determine an epileptologist's performance in identifying HV-induced absence seizures using video data collected from a smartphone when compared to the gold standard interpretation of the EEG. The exploratory goal is to develop machine learning based algorithms to identify HV-induced seizures.

Connect with a study center

  • Cincinnati Children's Hospital

    Cincinnati, Ohio 045229
    United States

    Site Not Available

  • Cincinnati Children's Hospital

    Cincinnati 4508722, Ohio 5165418 045229
    United States

    Site Not Available

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