Regulating Together in Tuberous Sclerosis Complex

Inclusion Criteria:

• Children ages 8-17 years inclusive with a documented clinical and/or geneticdiagnosis of TSC and exhibiting symptoms of behavioral dysregulation (identified onthe TAND Checklist having temper tantrums, aggressive outbursts, self-injury, and/orimpulsivity) are eligible for inclusion.

Additional inclusion/eligibility criteria include:

• Participants and their caregivers have access to a computer, phone, or tablet withvideo capability and stable internet connection. If lack of a device or internetservice is the sole barrier to eligibility/participation, interested individualswill be connected to a TSC Clinic social worker to link them to existing governmentand charity programs specifically addressing this disparity in underservedcommunities and households in need (e.g., the Affordable Connectivity Program).

• Participants must also be willing to participate in treatment sessions and haveminimal levels of functional verbal communication (child and their caregiver must befluent in English

• Child must have a minimum IQ>65 on the WASI-II at the screening/baseline visit).

Exclusion Criteria:

• Participants be on a stable medication regimen at least 4 weeks prior to enrollment

• Do not have a plan to start a new psychosocial intervention (e.g., individualpsychotherapy, family psychotherapy, group psychotherapy or social skills training)or behavior medication within 30 days prior to enrollment or at any point during thestudy. ----Participants with significant disruptive, aggressive, self-injurious orsexually inappropriate behaviors deemed potentially dangerous or overly disruptiveto the group dynamic/session, having significant co-occurring neuropsychiatricillness warranting other treatment approaches as determined by study clinician (e.g., substance use disorders, psychotic disorders, schizophrenia), or havingsignificant sensory impairment that would limit participation in interventioncurriculum/materials (e.g., blindness or uncorrected hearing loss) also will beexcluded.