A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Inclusion Criteria:

• Have a body mass index (BMI)

• ≥30 kilogram/square meter (kg/m²), or

• ≥27 kg/m² and <30 kg/m², or with at least 1 weight-related comorbidity

• Have had a stable body weight for the 3 months prior to randomization (<5%) bodyweight gain and/or loss.

Exclusion Criteria:

• Have a prior or planned surgical treatment for obesity, except prior liposuction orabdominoplasty, if performed >1 year prior to screening.

• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history ofketoacidosis or hyperosmolar coma.

• Have poorly controlled hypertension.

• Have signs and symptoms of any liver disease other than nonalcoholic fatty liverdisease.

• Have any of the following cardiovascular conditions within 3 months prior toscreening:

• acute myocardial infarction

• cerebrovascular accident (stroke)

• unstable angina, or

• hospitalization due to congestive heart failure.

• Have a history of symptomatic gallbladder disease within the past 2 years.

• Have a lifetime history of suicide attempts.