To Evaluate the Efficacy and Safety of HSK31679 in Chinese Patients With Non-Alcoholic Steatohepatitis (NASH) .

Inclusion Criteria:

1. Must be willing to participate in the study and provide written informed consent.

2. Male or female aged 18 ≤ age < 65 at the time of signing the informed consent

3. Must have had prior liver biopsy within 180 days of randomization with fibrosisstage 2 to 3 and a NAS of ≥4 with at least a score of 1 in each of the lobularinflammation and ballooning degeneration.

4. Must have confirmation of ≥8% liver fat content on MRI-PDFF.

5. Weight changes≤5% in the 6 weeks prior to randomization.If a historical biopsy is tobe used, patients must have had weight changed≤5%, too.

Exclusion Criteria:

1. History or presence of cirrhosis，hepatic decompensation or impairment defined aspresence of any of the following: history of esophageal varices, ascites, or hepaticencephalopathy, or hepatocellular carcinoma.

2. Use of high dose vitamin E (>400 IU/day)，polyunsaturated fatty acid orursodeoxycholic acid unless stable for ≥6 months prior to an eligible screeningliver biopsy. Use of thiazolidinediones, sodium-glucose co-transporter 2 inhibitorsor a complex oral anti-diabetic (OAD) regimen (3 or more OADs) unless stable for ≥3months prior to an eligible screening liver biopsy.

3. Use of Glucagon-like peptide 1 [GLP-1] agonist therapy (e.g.,liraglutide,semaglutide, dulaglutide and exenatide ) within 6 months prior to an eligiblescreening liver biopsy.

4. Use of drugs that have the potential to affect thyroid hormone production and/orinterfere with thyroid function.

5. Potent inhibitors of CYP2C8 such as gemfibrozil and trimethoprim are prohibited. Aninducer of CYP2C8, rifampicin, is prohibited.

6. Use of drugs historically associated with NAFLD/NASH for 2 weeks prior to aneligible screening liver biopsy, which include, but are not limited, to thefollowing: total parenteral nutritionamiodarone, methotrexate, systemicglucocorticoids (if use within 3 months prior to a biopsy is also not permitted),tamoxifen, tetracycline, estrogens at doses greater than those used for hormonereplacement or contraception, anabolic steroids , valproic acid, and knownhepatotoxins.

7. Regular use of drugs historically associated with NAFLD/NASH within 12 months priorto liver biopsy (including historical biopsy), which include, but are not limited,to the following:PPAR agonists (e.g. lanifibranor, Siglitazone sodium) ，FXR agonists (e.g., obecholic acid, HTD1801)，FGF21 analogs (e.g., AP025, efruxifermin ,pegozafermin(B1089-1001)) ; DGAT2 inhibitors (e.g., PF 6865571 and ION224),PDEinhibitors (e.g., ZSP1601) and other thyroid hormone receptor B agonists [e.g.,resmetirom（MGL-3196）、ASC41 and VK2809).

8. Lipid-lowering therapy that did not meet the following criteria: fenofibrate,ezetimibe stable for at least 3 months before randomization and remained unchangedduring study treatment, and statins stable for at least 4 weeks before randomizationand remained unchanged during study treatment.

9. Type 1 diabetes or uncontrolled Type 2 diabetes defined as:

• Hemoglobin A1c >9.5% at screening (patients with HbA1c >9.5% may berescreened),

• Insulin dose adjustment >20% within 60 days prior to enrollment,

• Requirement for glucagon-like peptide analogue (unless on a stable dose ≥ 6months prior to screening) or History of severe hypoglycemia (symptomatichypoglycemia requiring outside assistance to regain normal neurologic status).

10. Uncontrolled hypertension (either treated or untreated) defined as systolic bloodpressure >160 mmHg or a diastolic blood pressure >100 mmHg at screening.

11. Evidence of other forms of chronic liver disease including the following:biliarybypass, drug induced liver disease, alcoholic liver disease, autoimmune hepatitis,primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC),hemohemosis, Wilson's disease, α-1 antitrypsin deficiency, bile duct obstruction,primary or metastatic liver cancer, hepatitis B, or present Hepatitis virus (HCV)infection.

12. Thyroid diseases: hyperthyroidism and hypothyroidism. Thyroid peroxidase antibodies (TPOAb) or thyroglobulin antibodies (TGAb) that have been determined by theinvestigators to be clinically significant.

13. Myocardial infarction, unstable angina, percutaneous coronary intervention, coronaryartery bypass graft, or stroke within 6 months prior to screening.

14. New York Heart Association class III or IV heart failure, or known left ventricularejection fraction <30%.

15. Serum ALT or AST >5 × ULN; Serum ALP≥2× ULN；eGFR<60 mL/min/1.73m2；INR>1.5×ULN；platelets < 80×109/L.

16. Participation in an investigational new drug trial in the 90 days prior torandomization.

17. Any other condition which, in the opinion of the Investigator, would impedecompliance, hinder completion of the study, compromise the well-being of thepatient, or interfere with the study outcomes.