Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)

Key Inclusion Criteria:

• Body weight greater than or equal to (>=)45 kilogram (kg)

• Body mass index (BMI) less than or equal to (<=) 40 kg/ meter square (m^2)

• Diagnosis of PLSR for greater than (>)3 months as per criteria pre-specified in theprotocol

• Weekly average of daily NPRS score >=4 and <10 with limited variation in the 7-dayRun-in Period

Key Exclusion Criteria:

• More than 3 missing daily NPRS scores during the 7-day Run-in Period

• Moderate or severe painful neuropathy other than PLSR as pre-specified in theprotocol

• History of prior lumbar spine surgery (e.g., discectomies, laminectomies,foraminotomies, or fusion)

Other protocol defined Inclusion/Exclusion criteria may apply.