Repetitive Applications of Pruritogens and Effects of a Cutaneous-induced Pain Stimulation on Nonhistaminergic Itch Perception

Last updated: December 14, 2023
Sponsor: Aalborg University
Overall Status: Active - Recruiting

Phase

N/A

Condition

Pain

Treatment

Cowhage

Clinical Study ID

NCT06185582
N-20210046 2nd project
  • Ages 18-60
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

In This experiment, the investigators would like to test following hypotheses:

the pain stimulation applied at the same time of a pruriceptive stimulus will decrease the itch perception. Moreover, also the effect of the cutaneous pain stimulus location (same forearm of the pruriceptive stimulus versus the opposite forearm) on histaminergic and non-histaminergic itch will be investigated.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Healthy men and women
  • 18-60 years
  • Speak and understand English

Exclusion

Exclusion Criteria:

  • Pregnancy or lactation
  • Drug addiction defined as any use of cannabis, opioids, or other addictive drugs
  • Previous or current history of neurological (e.g. neuropathy), immunological (e.g.asthma, immune deficiencies, arthritis) musculoskeletal (e.g. muscular pain in theupper extremities,), cardiac disorder, or mental illnesses that may affect the results
  • Lack of ability to cooperate
  • Current use of medications that may affect the trial such as antihistamines,antipsychotics, and pain killers, as well as systemic or topical steroids
  • Skin diseases (e.g. atopic dermatitis, pruritus nodularis, eczema, psoriasis)
  • Moles, scars, or tattoos in the area to be treated or tested.
  • Consumption of alcohol or painkillers 24 hours before the study days and between these
  • Acute or chronic pain
  • Participation in other trials within one week of study entry (four weeks in the caseof pharmaceutical trials)

Study Design

Total Participants: 30
Treatment Group(s): 1
Primary Treatment: Cowhage
Phase:
Study Start date:
December 15, 2023
Estimated Completion Date:
June 30, 2025

Study Description

The phenomenon that pain inhibits pain is a well-known mechanism, but it is not known if pain is inhibiting itch. In this context, the aim of this project is to investigate the extent to which thermal or neurogenic short cutaneous pain can affect the itch perception. In particular, the project aims to understand any differences in itch perception when the painful stimulation is applied on the same forearm versus the opposite forearm. The hypothesis is that by applying a painful stimulus at the same time of an itchy stimulus, the itch sensitivity will decrease; probably due to an inhibitory process conducted by interneurons (Bhlbb5 interneuron) at central level.

Connect with a study center

  • Aalborg University

    Aalborg, 9220
    Denmark

    Active - Recruiting

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