Development of a Molecular Diagnostic Tool for Endometrial Cancer.

Inclusion Criteria:

• Post-menopausal women (≥1 year without menstruation) with AUB who present with:

1. Endometrium > 3mm by transvaginal ultrasound, OR

2. Endometrium ≤ 3mm who meet at least one of the following criteria: i. Persistent symptoms (more than one episode of metrorrhagia) ii. Heterogenousendometrium on transvaginal ultrasonography iii. Risk factors (BMI ≥ 30, use oftamoxifen, hormone replacement therapy (HRT), Lynch syndrome, BRCA mutation.

• Obtaining written informed consent

Exclusion Criteria:

• Women with an active pelvic infection.

• Women who have had viral infections with evidence of active and latent disease suchas Hepatitis B, Hepatitis C, and HIV infection. Patients who have had Hepatitis C inthe past but who have been successfully treated and in whom viral replication hasnot been observed in the last year will be included.