A Study of LY3841136 Compared With Placebo in Adult Participants With Obesity or Overweight

Inclusion Criteria:

W8M-MC-LAA1

• Are males and females who agree to abide by the reproductive and contraceptiverequirements

W8M-MC-CWMM:

• Have a BMI ≥27 kg/m²

• Have had a stable body weight for the 3 months prior to randomization (<5% bodyweight gain and/or loss)

Exclusion Criteria:

W8M-MC-LAA1

• Have any prior diagnosis of diabetes mellitus except gestational diabetes.

• Have any of the following cardiovascular conditions within 6 months prior toscreening:

• acute myocardial infarction

• cerebrovascular accident (stroke)

• unstable angina, or

• hospitalization due to congestive heart failure (CHF).

• Have a history of acute or chronic pancreatitis.

• Have an on-going or history of bradyarrhythmia and/or sinus bradycardia at screeningand baseline.

W8M-MC-CWMM

• Have a prior or planned surgical treatment for obesity, except prior liposuction orabdominoplasty, if performed >1 year prior to screening.

• Have type 1 diabetes mellitus, latent autoimmune diabetes in adults, or history ofketoacidosis or hyperosmolar coma.

• Have poorly controlled hypertension.

• Have a history of symptomatic gallbladder disease within the past 2 years

• Have signs and symptoms of any liver disease other than nonalcoholic fatty liverdisease.

• Have a lifetime history of suicide attempts.