Longevity in Russia

Last updated: February 20, 2024
Sponsor: Center for Strategic Planning, of the Federal Medical and Biological Agency
Overall Status: Active - Recruiting

Phase

N/A

Condition

Mild Cognitive Impairment

Dementia

Aging

Treatment

N/A

Clinical Study ID

NCT06268132
MLS90
  • Ages > 90
  • All Genders

Study Summary

This is an observational cohort study of long-living adults (participants aged 90 and above) from the Central Federal District of Russia.

The study seeks to determine the genetic and cellular and molecular determinants of healthy longevity and to assess the impact of lifestyle and socioeconomic and environmental factors on healthy longevity.

The study is expected to result in the development of a panel of markers of healthy longevity and/or a model of healthy aging based on the analysis of all factors under consideration.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Informed consent
  • 90 years of age or above

Exclusion

Exclusion Criteria:

  • Refusal to participate or to provide informed consent;
  • Any other criteria deemed reasons for exclusion by the Principal Investigator.

Study Design

Total Participants: 4000
Study Start date:
December 25, 2019
Estimated Completion Date:
December 31, 2025

Study Description

The study involves a long-term observation of a cohort of long-living adults. During the first visit, a medical professional will take a detailed medical history and perform a comprehensive geriatric assessment (for 15 geriatric syndromes), and physical examination. The participants will have their biomaterials sampled for basic and extended blood biochemistry testing, telomere length measurement, common urine tests and subsequent biobanking and additional studies: whole genome sequencing, DNA methylation analysis, transcriptome analysis, and 16S RNA sequencing of stool and saliva.

Follow-up checks will be carried out once a year by phone or during additional visits.

The study seeks to identify the genetic, epigenetic, and metagenomic determinants associated with the successful and unsuccessful aging phenotypes, mortality, and survival in long-living individuals.

Connect with a study center

  • RUSSIAN CLINICAL AND RESEARCH CENTER OF GERONTOLOGY, Pirogov Russian National Research Medical University of the Ministry of Healthcare of the Russian Federation

    Moscow, 129226
    Russian Federation

    Active - Recruiting

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