PET Imaging of Fibroblast Activation in Atherosclerosis

Last updated: February 25, 2024
Sponsor: Peking Union Medical College Hospital
Overall Status: Active - Recruiting

Phase

N/A

Condition

Atherosclerosis

Treatment

FAPI PET

Clinical Study ID

NCT06280287
FAPI-PLAQUE
  • Ages 18-90
  • All Genders

Study Summary

Fibroblast activation protein (FAP) is a fibroblast-specific marker expressed in atherosclerosis, associated with endothelial-to-mesenchymal transition and a rupture-prone plaque phenotype. This study aims to evaluate in-vivo fibroblast activation in carotid and coronary atherosclerotic diseases with FAPI PET and its correlation with histological vulnerability and clinical outcome.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • For the carotid stenosis group: patients with symptomatic carotid stenosis with >50%stenosis on carotid CTA; OR patients with unsymptomatic carotid stenosis with >70%stenosis on carotid CTA
  • For CAD group: patients with stable ischemic heart disease OR acute coronary syndrome,including ST-elevation MId, non-ST elevation MI, and unstable angina
  • signed informed consent

Exclusion

Exclusion Criteria:

  • Pregnancy, lactation, or intention to become pregnant during the study
  • Contradiction to MRI or CTA

Study Design

Total Participants: 150
Treatment Group(s): 1
Primary Treatment: FAPI PET
Phase:
Study Start date:
August 01, 2021
Estimated Completion Date:
December 31, 2025

Study Description

Fibroblast activation protein (FAP) is a fibroblast-specific marker expressed in atherosclerosis. Abundant FAP-expressing cells in atherosclerotic plaques co-express endothelial biomarkers involved in endothelial-to-mesenchymal transition. FAP upregulation is also associated with a rupture-prone plaque phenotype with a thin fibrous cap. Positron emission tomography (PET) with 68Ga-FAPI-04 has been demonstrated as a feasible method to image fibroblastic activation in the arterial wall. The current study aims to evaluate in-vivo fibroblast activation in carotid and coronary atherosclerotic diseases with FAPI PET and its correlation with histological vulnerability and clinical outcome.

Connect with a study center

  • Peking Union Medical College Hospital

    Beijing, Beijing 100730
    China

    Active - Recruiting

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