Creation of a Clinical Database for the Study of Phenotypic Variability in Motor Neuron Diseases

Last updated: March 15, 2024
Sponsor: Istituto Auxologico Italiano
Overall Status: Active - Recruiting

Phase

N/A

Condition

Amyotrophic Lateral Sclerosis (Als)

Myasthenia Gravis (Chronic Weakness)

Treatment

N/A

Clinical Study ID

NCT06318585
23C306
  • Ages > 18
  • All Genders

Study Summary

Study Description: Characterization of Motor Neuron Disease Phenotypes

The goal of this observational study is to understand the clinical presentation of motor neuron disease (MND) in patients attending the Neurology Department of the Istituto Auxologico Italiano. The main questions it aims to answer are:

  • What are the specific clinical phenotypes associated with MND?

  • How can these phenotypes contribute to a better understanding of the disease's underlying mechanisms and improve prognostic accuracy?

Participants will undergo:

  • Clinical evaluation using validated scales

  • Neurophysiological and neuroradiological instrumental assessment

  • Neuropsychological evaluation

  • Collection of biological materials for genetic screening and biomarker assessment, if necessary.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • diagnosis of ALS or other motor neuron disease

Exclusion

Exclusion Criteria:

  • refusal to participate to the study

Study Design

Total Participants: 200
Study Start date:
April 03, 2023
Estimated Completion Date:
December 31, 2026

Connect with a study center

  • Ospedale San Luca

    Milano, MI 20149
    Italy

    Active - Recruiting

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