The Role of Oxytocin in Regulating Blood Glucose

Last updated: April 2, 2024
Sponsor: University Hospital, Gentofte, Copenhagen
Overall Status: Active - Recruiting

Phase

N/A

Condition

Metabolic Disorders

Treatment

Placebo

Oxytocin

Clinical Study ID

NCT06334172
H-23071221
  • Ages 20-50
  • Male

Study Summary

Investigating the effect of oxytocin on pancreatic endocrine functions by determining insulin and glucagon secretion within physiological ranges of plasma glucose.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • BMI 19-25 kg/m2

Exclusion

Exclusion Criteria:

  • Diabetes
  • Heart-, liver or kidney disease
  • More than 14 units of alcohol weekly, or drug abuse
  • Smoking or any kind of nicotine products
  • Alanin aminotransferase (ALAT) ≥ 2 × normal range
  • Estimated glomerular filtration rate (eGFR) < 60 ml/min/1,73m2 or creatinine abovenormal range
  • Blood pressure > 140/90
  • Hemoglobin < normal range
  • Corrected QT Interval (Qtc) >0,45 sec. at electrocardiogram (ECG) at screening
  • Known disease in the pituitary gland or previous pituitary surgery
  • Any other disease/condition which the trial managers believe may affect participationin the trial

Study Design

Total Participants: 20
Treatment Group(s): 2
Primary Treatment: Placebo
Phase:
Study Start date:
January 01, 2024
Estimated Completion Date:
December 31, 2026

Study Description

Insulinotropic effects of oxytocin will be examined in 20 healthy men with body mass index (BMI) < 27 kg/m2, during a graded glucose infusion test with concomitant intravenous infusion of synthetic oxytocin or placebo in a randomized, double-blinded design. This will determine the effect of oxytocin on glucose-stimulated insulin and glucagon secretion. Additional changes in plasma/serum concentrations of C-peptide, glucose, glucose-dependent insulinotropic polypeptid (GIP), glucagon-like peptide 1 (GLP-1), and lipids will be assessed.

Connect with a study center

  • Center for Clinical Metabolic Research, Gentofte Hospital

    Hellerup, Capital Region 2900
    Denmark

    Active - Recruiting

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