Mental Imagery and Targeted Memory Reactivation in Insomnia

Last updated: April 22, 2024
Sponsor: University Hospital, Geneva
Overall Status: Active - Recruiting

Phase

N/A

Condition

Anxiety Disorders

Treatment

Sleep Hygiene + Odor

Sleep Hygiene

Imagery Rescripting (IR)

Clinical Study ID

NCT06335784
2023-00456
  • Ages 18-45
  • All Genders

Study Summary

In this clinical trial, the investigators test whether mental Imagery Rescripting (IR), a technique where the individual is instructed to transform a negative memory or image into a positive one, and olfactory Targeted Memory Reactivation (TMR), a technique used to strengthen memories, can reduce hyperarousal and insomnia severity in patients with Insomnia Disorder (ID).

Patients with ID will be randomized into four groups: in the first group (SH group), patients will have 4 weekly sessions (1 session/week) of a minimal intervention for insomnia (sleep hygiene information) in the presence of an odorless diffuser, which will be also used during the night. In the second group (IR group), patients will use IR during wakefulness to induce a state of relaxation and positive emotionality. More specifically, during 4 weekly sessions of IR, patients will imagine a negative scenario related to their pre-sleep images or current concerns (e.g., social interactions, self-image, sleep problem, nightmares) and transform it into a positive script. They will then perform IR every day for 4 weeks at home in the presence of an odorless diffuser, which will be also used during the night. In the third group, patients will undergo the same 4 weekly IR sessions and an odor will be paired to the positive imagery and will be diffused during the night (TMR group). Patients from this group will also perform IR every day for 4 weeks at home. Finally, the fourth group (OA group) will receive 4 weekly sessions of sleep hygiene instructions in the presence of an odor, which will be also used during the night.

Clinical evaluation of insomnia severity before and after the intervention will take place using the Insomnia Severity Index (ISI, primary outcome measure).

At the end of these interventions, patients with persistent symptoms will benefit from an alternative experimental treatment ("rocking bed") in which they will be cradled for one night.

The investigators hypothesize that patients treated with IR will have significantly reduced insomnia severity compared to participants who received a minimal intervention. They also hypothesize that patients of the TMR group, will have more reduced ID severity compared to participants performing IR and with an odorless diffuser, therefore without an association (IR group). Finally, they hypothesize that one night of sleeping in a rocking bed will improve objective measures of sleep in ID compared to a stationary condition.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Age between 18 and 45 years
  • Insomnia disorder according to the International Classification of Diseases 3 (ICSD-3)
  • ISI > 10
  • PSQI > 5
  • No other current treatment for Insomnia

Exclusion

Exclusion Criteria:

  • patients with another psychiatric disorder requiring acute treatment according toDSM-5
  • patients with medical (e.g. neurological disorders) or other disorders explaining thepredominant complaint of insomnia (e.g., sleep apneas with ODI>15/h, restless legssyndrome, periodic limb movements with PLM>15, chronic pain)
  • patients with significant substance use/withdrawal
  • patients with heavy smoking
  • known pregnancy
  • patients suffering from anosmia, olfactory related issues and respiratory pathology

Study Design

Total Participants: 120
Treatment Group(s): 5
Primary Treatment: Sleep Hygiene + Odor
Phase:
Study Start date:
April 22, 2024
Estimated Completion Date:
August 31, 2027

Connect with a study center

  • Center for Sleep Medicine

    Geneva,
    Switzerland

    Active - Recruiting

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