Impact of Sleep Disorders on Innate Immunity in COVID-19 Patients

Last updated: March 29, 2024
Sponsor: Parc Taulí Hospital Universitari
Overall Status: Active - Recruiting

Phase

N/A

Condition

Sleep Disorders

Sleep Apnea Syndromes

Covid-19

Treatment

Influvac Tetra

Clinical Study ID

NCT06341374
2023/5079
  • Ages 18-70
  • All Genders
  • Accepts Healthy Volunteers

Study Summary

Sleep is an important modulator of the immune response, whereby sleep disturbances (ie, poor sleep quality, insufficient sleep and/or primary sleep disorder, obstructive sleep apnea (OSA)) contribute to inflammatory disease risk and dysregulation of immune response in front of infectious agents.

The objective of this study is to evaluate the impact of undiagnosed and non-treated sleep disorders on innate immunity in a cohort of COVID-19 patients and the role of trained immunity induced by influenza vaccination in the innate immune response.

Eligibility Criteria

Inclusion

Inclusion Criteria:

  • Participants over 18 years old with diagnosis of COVID-19 during first year ofcoronavirus pandemic in March-June 2021.

Exclusion

Exclusion Criteria:

  • >70 years and <18 years
  • Recent COVID-19 (<6 months)
  • Other infection (<3 months)
  • Obstructive sleep apnea in treatment with CPAP prior to COVID infection.
  • Immunosuppressed

Study Design

Total Participants: 50
Treatment Group(s): 1
Primary Treatment: Influvac Tetra
Phase:
Study Start date:
November 06, 2023
Estimated Completion Date:
September 30, 2024

Study Description

Sleep and immune system have reciprocal relationship. Sleep has a restorative role on immune system, influencing innate and adaptive immunity and sleep disorders can decrease immune response.

Healthy innate immunity is crucial into regulation of the response against SARS-CoV-2.

The hypothesis of the study is that the innate immunity response is blunted by sleep disorders and, this mitigated immune response, could influence on COVID-19 severity. Impaired immune response in patients with sleep disorders could be ameliorated inducing trained immunity by influenza vaccine.

Connect with a study center

  • Hospital Universitari Parc Tauli

    Sabadell, Barcelona 08208
    Spain

    Active - Recruiting

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