A Study of MK-1084 Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant, Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004)

The main inclusion and exclusion criteria include but are not limited to the following:

Inclusion Criteria:

• Has a histologically or cytologically confirmed diagnosis of NSCLC

• Has newly diagnosed Stage IV NSCLC by American Joint Committee on Cancer (AJCC)Staging Manual, Version 8

• Has measurable disease based on RECIST 1.1

• Has provided tumor tissue that demonstrates PD-L1 expression in ≥50% of tumor cells

• Has provided tumor tissue that demonstrates presence of KRAS G12C mutation

• Has life expectancy of at least 3 months

• Has Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 assessedwithin 7 days before randomization

• For participant assigned male sex at birth: If capable of producing sperm,participant must agree to the following during the study treatment period and for atleast 10 days after the last dose of oral intervention: Either be abstinent or mustagree to use male condom plus additional contraceptive method.

• For participant assigned female sex at birth: Either be a person of nonchildbearingpotential (PONCBP) or must agree to follow contraceptive guidance during the studytreatment period and for at least 10 days after the last dose of oral interventionand 120 days after the last dose of pembrolizumab. Must abstain from breastfeedingduring the study intervention period and for at least 120 days after studyintervention.

• Human immunodeficiency virus (HIV)-infected participants must have well controlledHIV on antiretroviral therapy (ART).

• Participants who are hepatitis B surface antigen (HBsAg) positive are eligible ifthey have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeksand have undetectable HBV viral load before randomization

Exclusion Criteria:

• Diagnosis of small cell lung cancer

• Has active inflammatory bowel disease requiring immunosuppressive medication orprevious clear history of inflammatory bowel disease

• Has a known history of, or active, neurologic paraneoplastic syndrome

• Has an active infection requiring systemic therapy

• Has uncontrolled, significant cardiovascular disease or cerebrovascular diseaseincluding New York Heart Association Class III or IV congestive heart failure,unstable angina, myocardial infarction, uncontrolled symptomatic arrhythmia,prolongation of QT interval corrected for heart rate by Fridericia's formula (QTcF)interval to >470 ms, and/or other serious cardiovascular and cerebrovasculardiseases within the 6 months preceding study intervention

• Is considered a poor medical risk due to a serious, uncontrolled medical disorder ornonmalignant systemic disease. Examples include, but are not limited to,uncontrolled major seizure disorder, unstable spinal cord compression, or superiorvena cava syndrome.

• Has one or more of the following ophthalmological findings/conditions: intraoculardiagnosis of central serous retinopathy, retinal vein occlusion, or retinal arteryocclusion, diagnosis of retinal degenerative disease pressure >21 mm Hg and/or anydiagnosis of glaucoma

• Is unable to swallow orally administered medication, or has a gastrointestinaldisorder affecting absorption (eg, gastrectomy, partial bowel obstruction, ormalabsorption)

• Received prior systemic anticancer therapy for their metastatic NSCLC

• Received prior therapy with an anti-programmed cell death-1 (anti-PD-1),anti-programmed cell death-ligand 1 (anti-PD-L1), or anti PD-L2 agent, or with anagent directed to another stimulatory or coinhibitory T-cell receptor within 12months before diagnosis of metastatic NSCLC

• Has received radiotherapy within 2 weeks of start of study intervention

• Has received a live or live-attenuated vaccine within 30 days before the first doseof study intervention. Administration of killed vaccines is allowed.

• Has received an investigational agent or has used an investigational device within 4weeks prior to study intervention administration

• Has known active central nervous system (CNS) metastases and/or carcinomatousmeningitis.

• Diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (indosing exceeding 10 mg daily of prednisone equivalent) or any other form ofimmunosuppressive therapy within 7 days prior to the first dose of studyintervention

• Active autoimmune disease that has required systemic treatment in the past 2 years

• History of (noninfectious) pneumonitis/interstitial lung disease that requiredsteroids or has current pneumonitis/interstitial lung disease

• HIV-infected participants with a history of Kaposi's sarcoma and/or MulticentricCastleman's Disease

• History of allogeneic tissue/solid organ transplant

• Has not fully recovered from any effects of major surgical procedure. Surgicalprocedures that required general anesthesia must be completed at least 2 weeksbefore first study intervention administration.