tFUS Induced Transient Scotoma for Individual Dosing

Inclusion Criteria:

• Male or female

• Age 18-70

• Normal or corrected-to normal vision and hearing

• No neurological or psychological illness

Exclusion Criteria:

• Diagnosis of any depressive or anxiety disorder

• Diagnosis of schizophrenia or bipolar disorder

• Current use of any non-prescribed psychoactive medications or drugs

• Contraindication to enter the MRI environment.

• Pregnancy (or suspected/possible pregnancy or plan to become pregnant in the shortterm).

• Urine Pregnancy Test: If the subject is a woman of childbearing potential and /or aman capable of fathering a child before, during, and/or after participationprecaution should be taken. Examples of acceptable methods of birth control forparticipants involved in the study include: birth control pills, patch, IUD, condom,sponge, diaphragm with spermicide, or avoiding sexual activity that could cause thesubject to become pregnant.

• Inability to adhere to treatment schedule.

• Initiation of new antidepressant treatment at the time of study randomization.

NOTE: There will be no exclusion based upon gender or minority status. We anticipate that at least 50% of the participants will be women. The percentage of minority participants is expected to be at least 5%. We will make vigorous attempts to increase this number by posting advertisement flyers in minority communities.

Children, prisoners, and institutionalized individuals will not be recruited, because they are beyond the scope of the objectives. Moreover, we will emphasize that participation in this study is completely voluntary. Recruitment of women and minorities has been addressed above. Non-English speaking subjects will not be recruited because they may not be able to understand instructions, which could undermine the validity of the results.