A Study of Tirzepatide in Adolescents With Obesity and Weight-Related Comorbidities (SURMOUNT-ADOLESCENTS-2)

Inclusion Criteria:

• Have body mass index (BMI) equal to or above the 95th percentile for age and sex (onage and gender-specific growth chart for diagnosis of obesity) with at least 2 ofthe following predefined weight-related comorbidities: hypertension, prediabetes andhypertriglyceridemia.

• Have history of at least 1 self-reported unsuccessful dietary effort to lose weight.

• Are capable of giving signed informed consent by a legal representative or assent bya study participant (when applicable).

Exclusion Criteria:

• Have undergone or plan to undergo a weight reduction procedure during the study,such as, but not limited to

• gastric bypass

• sleeve gastrectomy

• restrictive bariatric surgery, such as Lap-Band gastric banding, or

• any other procedure intended to result in weight reduction.

• Have a self-reported, or by parent or legal guardian where applicable, decrease inbody weight greater than 5 kg (11 lbs) within 90 days before screening irrespectiveof medical records

• Have type 1 diabetes or history of ketoacidosis, or hyperosmolar state

• Have type 2 diabetes or have a HbA1c > 6.4% at screening

• Have a history of chronic or acute pancreatitis

• Have a family or personal history of medullary thyroid carcinoma or multipleendocrine neoplasia syndrome type 2