Efficacy and Safety of Oral Azelaprag Plus Once Weekly Tirzepatide Compared with Tirzepatide Alone in Participants with Obesity Aged 55 Years and Over

Inclusion Criteria:

1. Male or female, 55 years of age or older at the time of signing the informedconsent.

2. Have a BMI between 30 and 40 kg/m2 inclusive at the time of screening.

3. Have a history of at least 1 self-reported unsuccessful dietary effort to lose bodyweight.

Exclusion Criteria:

1. Have diagnosis of type 1 diabetes (T1D) or Type 2 diabetes (T2D) mellitus.

2. Have a self-reported change in body weight greater than 5 kg (11 lbs) within 90 daysprior to screening.

3. Have a prior or planned surgical treatment or device-based therapy for obesity.

4. Have a family or personal history of medullary thyroid carcinoma (MTC) or multipleendocrine neoplasia syndrome type 2 (MEN-2).

5. Have an uncontrolled thyroid disease.

6. Have obesity induced by endocrinological disorders.

7. Have biopsy-confirmed nonalcoholic steatohepatitis (NASH), also known as metabolicdysfunction-associated steatohepatitis (MASH).

8. Have a known history or presence of severe active acute or chronic livers disease oracute or chronic pancreatitis, or exocrine pancreatic insufficiency.

9. Have a known history or presence of symptomatic gallbladder disease within the past 2 years.

10. Have a medically significant cardiovascular condition.

11. Have a history of active or untreated malignancy within the last 5 years.

12. Have a history of significant active or unstable major depressive disorder or othersevere psychiatric disorder within the last 2 years.

13. Have any lifetime history of a suicide attempt.

14. Have a known clinically significant gastric emptying abnormality.

15. Have had previous or are currently on treatment with a GLP-1R agonist or tirzepatide (a dual agonist of GLP-1 and GIP receptors).

16. Are currently using warfarin.

17. Have used any weight loss drugs, including herbal or nutritional supplements, within 90 days of screening.

18. Have current or history of treatment with medications that may cause significantweight gain within 90 days of screening.