The Effects of Bio Gelee Royale Forte on Immune Health in Healthy Adults

Inclusion Criteria:

1. Males and females between 18-65 years of age, inclusive

2. Females not of child-bearing potential, defined as those who have undergone asterilization procedure (e.g. hysterectomy, bilateral oophorectomy, bilateral tuballigation, complete endometrial ablation) or have been post-menopausal for at least 1year prior to screening Or, Individuals of child-bearing potential must self-report confirmation they are notpregnant, do not plan to become pregnant, and agree to use a medically approvedmethod of birth control for the duration of the study. All hormonal birth controlmust have been in use for a minimum of three months. Acceptable methods of birthcontrol include:

• Hormonal contraceptives including oral contraceptives, hormone birth controlpatch (Ortho Evra), vaginal contraceptive ring (NuvaRing), injectablecontraceptives (Depo-Provera, Lunelle), or hormone implant (Norplant System)

• Double-barrier method

• Intrauterine devices

• Non-heterosexual lifestyle or agrees to use contraception if planning onchanging to heterosexual partner(s)

• Vasectomy of partner at least 6 months prior to screening

• Abstinence

3. At least two self-reported incidences of URTI in the last 12 months

4. Agrees to maintain current lifestyle as much as possible throughout the study,including diet, exercise, and sleep

5. Agrees to maintain medications/supplements (particularly those used for immunitysupport) as much as possible throughout the study and not add new supplements totheir routine

6. Able and willing to complete all study assessments

7. Provided voluntary and informed consent to participate in the study

8. Generally healthy as determined by medical history with no unstable diagnosedmedical conditions

Exclusion Criteria:

1. Individuals who are pregnant, breast feeding, or planning to become pregnant duringthe study

2. Allergy, sensitivity, intolerance, or dietary restriction preventing consumption ofinvestigational product or placebo ingredients

3. Self-reported allergy to bees or other insects

4. Self-reported autoimmune disease or are immune compromised due to other factors

5. Self-reported current or anticipated severe environmental allergies during the studyperiod requiring medication or need for allergy shots

6. Self-reported ongoing diagnosis of acute or chronic respiratory illness (e.g.,asthma, chronic bronchitis, sinusitis, pharyngitis, chronic obstructive pulmonarydisease (COPD))

7. Self-reported ongoing and unstable diseases/conditions in the past three months,including:

8. Arthritis and joint diseases

9. Gastrointestinal diseases

10. Hypertension

11. Type I or type II diabetes

12. Cardiovascular disease

13. Kidney diseases

14. Liver diseases

15. Thyroid condition

16. Self-reported surgery in the past three months or individuals who have plannedsurgery during the course of the study

17. Self-reported cancer, except skin basal cell carcinoma completely excised with nochemotherapy or radiation with a follow up that is negative. Volunteers with cancerin full remission for more than five years after diagnosis are acceptable

18. Alcohol intake average of >2 standard drinks per day

19. Alcohol or drug abuse within the last 12 months that has required treatment

20. Current use of prescribed and/or over-the-counter (OTC) medications/supplements thatmay impact the efficacy and/or safety of the investigational product

21. Participation in other clinical research studies 30 days prior to screening

22. Individuals who are unable to give informed consent

23. Any other condition or lifestyle factor that may adversely affect the participant'sability to complete the study or its measures or pose significant risk to theparticipant